In knockout male mice, VDR
null mutant were found to have gonadal insufficiency.
Spearman correlation test was used to determine the correlation between serum VDR
levels and bacterial index.
is the target of active vitamin D, which is located in the center of the vitamin D pathway.
In Saudi Arabia, a recent study found that VDR
genetic variants were significantly associated with T2DM as well as cholesterol disorders that are often associated with type 2 diabetes - dyslipidemia, hypertriglyceridemia, and low high-density lipoproteins (HDL) levels.
Effect of Budesonide and Calcitriol on the Expression of GR, VDR
, and RXR in Asthmatic Mice.
Human umbilical vein endothelial cells (HUVECs) were divided into four groups based on treatment, as follows: 200 [micro]g/ml of HSA and 100 mg/dl of glucose (normal group); 200 [micro]g/ml of AGE-HSA and 250 mg/dl of glucose (diabetic group); 200 [micro]g/ml of AGE-HSA and 250 mg/dl of glucose with vitamin D (50 ng/ml) (VD treatment group); and 200 [micro]g/ml of AGE-HSA, 250 mg/dl of glucose, vitamin D (50 ng/ml), and VDR
siRNA (VD antagonist group).
Logistic regression analysis showed that there was no significant association of these studied SNPs in the VDR
gene regarding the severity of childhood ASD (Table 4).
The results in Figure 2 showed that the 25(OH)D receptor (VDR
) mRNA expression in hypertension group was lower than that in control group(P=0.003), even after adjusted BMI (P=0.017).
The importance of the vitamin D-endo/para/autocrine system is further confirmed by the correlation between T1D development, osteoporosis, and the presence of functionally defective alleles in Cyp27b1 and Vdr
genes [10, 11].
The aim of this study was to measure the concentrations of 25-hydroxyvitamin D (25(OH) D), IL-17, IL-23 and TGF-[beta], and the expression of CYP27B1 and VDR
, in the decidua of women with RSA in the first trimester of pregnancy.
 Vitamin D receptor (VDR
) is a member of the steroid hormone receptor family that binds the active form of Vitamin D (1,2,5-dihydroxyvitamin D3) and interacts with the target cell nuclei to produce variety of biological effects.