VGFRValue Generated Fund Raising
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MDSCs constitute tumor growth factor-[beta] (TGF-[beta]), vascular endothelial growth factor (VGFR), hypoxia-induced factor 1 (HIF 1), fibroblast growth factor, reactive oxygen species and also MMP-9 to form a suitable environment for neo-angiogenesis for tumor development (10).
(29) Complete or partial loss of E-cadherin can be induced by growth factor stimulation including transforming growth factor beta (TGF-[beta]), (30) epidermal growth factor receptor (EGFR), (31) and vascular endothelial growth factor (VGFR), (32) and hypoxia, and is a hallmark of epithelial-to-mesenchymal transition, a common phenomenon during cancer progression and invasion.