Our demonstration of the ability of permethrin to antagonize deltamethrin-induced VGSC activation indicates that permethrin also interacts with VGSCs in cerebrocortical neurons.
Studies of binary combinations of pyrethroids indicate that type I and type II compounds may act competitively on VGSCs (Motomura and Narahashi 2001; Song et al.
A comprehensive study of the relative potencies of pyrethroids on VGSCs in intact mammalian neurons has not previously been undertaken.
To confirm the role of VGSCs in pyrethroid-induced increases of [Na.
influx; thus, we sought to confirm that they interacted with VGSCs in mouse neurons.
VGSCs are well-established targets of pyrethroid effects and clearly contribute to the insecticidal and toxicological actions of these compounds (Narahashi 1996).
VGSC recorded a $25,000 for severance and accruals related to the sale of particular assets.
The writeoff for the wholly-owned subsidiaries was $361,000 after tax, and $943,000 for VGSC and VGDC.