VHLDVon Hippel-Lindau Disease
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Another key finding that emerged from these studies was the role of VHLD gene loss, with resultant activation of the angiogenic protein "hypoxia inducible factor.
The mean age (37 years) of patients with renal cell carcinoma in VHLD is similar to the mean age of occurrence of PCE (35 years, our analysis).
The possibility of VHLD should be considered in all patients with PCE, since they may be at risk of developing other VHLD-associated tumors.