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In 2002, the first COX subunit isoform-knockout model was introduced, in which the gene encoding isoform VIaH was deleted in mice [179].
While rodents and most other mammals have a heart-type isoform, COX VIIIH (also known as COX VIII1), with an expression pattern similar to that of COX VIaH and VIIaH in the heart and skeletal muscle, the gene became a pseudogene in the stem of the catarrhines and is thus no longer active in humans [200].
Richman et al., "Cardiac dysfunction in mice lacking cytochrome-c oxidase subunit VIaH," American Journal of Physiology.