Among these altered genes, a total of 11 genes (ATP2A1, ERP27, FKBP1B, MBIP, PPIC, PRKCZ, VIPR1
, PRLR, NIM1K, LOC100355813, and MMP1) were appeared in both model and SXSM originated differentially expressed genes [Supplementary Figure 1] [SUPPORTING:1] Moreover, the expressions of nine of them (ATP2A1, ERP27, FKBP1B, MBIP, PPIC, PRKCZ, VIPR1
, PRLR, and NIM1K) were restored by SXSM in model rabbits [Table 1].
There are 8 out of 10 downregulated DEGs that are downregulated in Group II compared with those in Group I, namely VIPR1
, SLC6A4, NECAB1, LEPREL1, ITLN2, HSD17B6, HHIP, and CRTAC1 and 14 out of 57 upregulated DEGs that are upregulated in Group II compared with those in Group I, namely TRIM2, TP63, TMPRSS4, SPP1, SIX4, MMP1, ITGB8, GOLM1, CP, COL17A1, CLIC6, CDH3, CD24, and C12orf75.
Following the discovery of PACAP, it was found that VIP and PACAP act as endogenous ligands for the same receptors, which are three heterotrimeric GPCRs: PAC1, VPAC1 (or VIPR1
), and VPAC2 (or VIPR2), each with a distinct expression pattern.