VKOR

AcronymDefinition
VKORVitamin K Epoxide Reductase
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References in periodicals archive ?
The enzyme VKOR converts oxidized vitamin K back to an active vitamin K form, thus conserving vitamin K.
"Derivatives of 4-hydroxycoumarin (including warfarin and acenocoumarol) specifically inhibit VKOR, thus preventing the recycling of vitamin K."
The Vitamin-K epoxide reductase (VKOR) enzyme hydroxylates vitamin K and it converts it into active vitamin K (Vit-K(H2)).
El descubrimiento de las variantes alelicas del citocromo P-450 (CYP2C9), principal metabolizador de la warfarina, y del complejo de la VKOR, permitio demostrar que los factores geneticos estan implicados en la gran variabilidad individual y la mayor tendencia hemorragica que se observa en algunos individuos anticoagulados (87).
Warfarin inhibits vitamin K epoxide reductase (VKOR), [5] an enzyme complex responsible for recycling reduced vitamin K, through interaction with subunit protein 1 (VKORC1).
Additionally, variation in apolipoprotein E (29), multi-drug resistance 1 (MDR1) (27), calumenin (30), and possibly genes encoding other components of the VKOR complex (11) may also play important roles.