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-1639 G>A, expressed as VKORC 1 GG, is made up of homozygote normal (wild) genotypes.
In terms of INR levels of the patient group, no statistical difference was found between VKORC 1 and CYP2C9 haplotypes (p=0.305 and p=0.088, respectively), whereas a significant difference was found on weekly warfarin dosages of VKORC 1 homozygote normal GG and CYP2C9 *1/*1 homozygote normal (wild) carriers (p=0.02 and p=0.034, respectively) (Table 4).
In terms of the frequency of visits to the emergency service, no statistical difference was found either for CYP2C9 or for VKORC 1 (Table 5).
No statistical difference was established between CYP2C9 and VKORC 1 haplotypes in terms of complications due to bleeding (p>0.05 and p=0.576, respectively) (Table 6).
Moreover, it was seen that carriers of VKORC 1 homozygote normal GG and CYP2C9 *1/*1 homozygote normal (wild) had a higher dosage requirement for warfarin compared with the other genotypes.
The VKORC 1 allele most frequently seen in our study was heterozygote type AG haplotype, but in VKORC 1 genotypes, the most common mutation that affected the dosage regulation were 1173, 3730, and -1639 single nucleotide polymorphisms (5-7).
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- VKH disease
- VKH syndrome
- VKH-like disease
- VKH-like syndrome