VLCFA

AcronymDefinition
VLCFAVery Long-Chained Fatty Acid
References in periodicals archive ?
Plasma VLCFA levels were determined by measuring unsaturated lysophosphatidylcholine fatty acid esters, which are biomarkers for VLCFAs in X-ALD.
Viking Therapeutics Study of VK0214 in Mouse Model of X-ALD Demonstrates Significant Reductions in Plasma and Tissue VLCFAs
The first step of VLCFA synthesis is condensation, which is carried out by one of ELOVL1-7, each with different FA substrate preferences.
Rapamycin inhibits expression of elongation of very-long-chain fatty acids 1 and synthesis of docosahexaenoic acid in bovine mammary epithelial cells
Kranial MR bulgusu olan bir hastada klinik bulgu olmasa da ALD suphesini dislamak icin serum VLCFA duzeyleri degerlendirilmelidir.
Difficulties with diagnosis and differential diagnosis in childhood cerebral phenotype of adrenoleukodystrophy: a case report/Cocukluk cagi serebral tip adrenolokodistrofi'de tani ve ayirici tani zorluklari: bir olgu sunumu
The findings of primary adrenocortical failure together with mild spastic paraparesis, ataxia, and an elevated plasma level of VLCFA established the diagnosis of AMN.
Uncommon cause of acute adrenal failure/Akut surrenal yetersizliginin seyrek rastlanan bir nedeni
Diagnosis is made by MRI and by measuring plasma VLCFA levels.
Newborn screening for X-linked adrenoleukodystrophy on the horizon
14]C]-radio-labeled VLCFA substrates and one of two available methods: either in intact human skin fibroblasts cultured in monolayer (5); or in isolated fibroblasts permeabilized with digitonin (6).
Method for measurement of peroxisomal very-long-chain fatty acid ([beta]-oxidation in human skin fibroblasts using stable-isotope-labeled tetracosanoic acid
and yeast, Miller and Kunst (1997) proposed that of the four enzymes involved in VLCFA biosynthesis, the two reductases and the dehydrase are expressed throughout the plant and are common to all microsomal FAE systems.
Improving Erucic Acid Content in Rapeseed through Biotechnology: What Can the Arabidopsis FAE1 and the Yeast SLC1-1 Genes Contribute?(1,2)
ALD is characterized by abnormal blood levels of complex saturated fatty acids known as VLCFAs (very-long-chain fatty acids).
Lorenzo's oil - more than just a great movie
Abnormal plasma samples were those leftover from patients with peroxisomal diseases referred to our laboratory and that gave abnormal VLCFA results.
Determination of L-pipecolic acid in plasma using chiral liquid chromatography--electrospray tandem mass spectrometry
ALD is usually diagnosed by plasma VLCFA analysis [1, 8], sometimes followed by measurement of (3-oxidation activity in cultured skin fibroblasts [9] and mutation analysis of the ALD gene [2,10-16].
Very long chain fatty acid analysis of dried blood spots on filter paper to screen for adrenoleukodystrophy
NeuroVia's lead candidate NV1205, is a small molecule therapeutic that showed the ability to reduce levels of VLCFAs in brain, adrenal tissue and blood of mice lacking a functioning ABCD1 gene.
NeuroVia Closes USD 14m Series A Financing Round; Will Fund X-ALD Disease Treatment
Buildup of VLCFAs in the central nervous system contributes to neurodegeneration in CALD.
Bluebird bio Touts Topline Interim Clinical Data from Starbeam Study of Lenti-D Drug Product in Cerebral Adrenoleukodystrophy
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