VLPOVentrolateral Preoptic Area
VLPOVirginia Lakes Pack Outfit (California)
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Once activated, the VLPO triggers the release of gamma aminobutyric acid (GABA) in the brainstem.
VLPO is also regulated by the SCN, which is the body's internal clock, generating a circadian rhythm that dictates we sleep at night and are wakeful during the day.
In the first two hours after glucose was injected directly into the VLPO, mice fell into a deep sleep called slow-wave sleep faster and stayed there longer than mice injected with a nonsugar solution.
VLPO neurons can directly sense the glucose in their neighborhood, other experiments revealed.
continent in VLPO area increases; tuberomammillary nucleus [TMN] and LC decrease) [26].
The contemporary theory for the mechanism of NREM sleep thus suggests a reciprocal interaction between two antagonistic neurons in the VLPO of the anterior hypothalamus and wake-promoting neurons in the tuberomammillary nuclei of the posterior hypothalamus, as well as locus coeruleus, dorsal raphe, basal forebrain and mesopontine tagmentum (6,20).
Further experiments revealed that isoflurane works by changing how these VLPO neurons respond to potassium atoms, though exactly how that happens isn't clear.
The VLPO region doesn't contain GABA receptors, however.