Significant predictors of extended anticoagulation treatment including being older than 65 years old, having chronic heart failure, pulmonary embolism at presentation, and recurrent VTE
during anticoagulation, the researchers also reported.
Generally, in the setting of an acute or recurrent VTE
, initial therapy with a parenteral anticoagulant (heparin or low-molecular-weight heparins [LMWH]) should be immediately instituted in patients with a gynecologic malignancy, unless there is evidence of active bleeding or any other contraindication for the use of an anticoagulant.
10] With regard to VTE
prophylaxis in gynaecological surgery, the literature is much scantier, but it is likely to be as underutilised as in other disciplines.
Prof Rangan said: "The ability to grade the risk and monitor effectiveness of intervention would increase health outcomes for patients at risk of VTE
and also decrease longterm morbidity while also offering significant savings to the NHS through better patient management.
events are classified as unprovoked (spontaneous) or provoked (occurring in the presence of major triggers; surgery, trauma, immobilization, cancer, or central venous catheters).
The Multiple Environmental and Genetic Assessment (MEGA) study (6) indicated that cancer patients have a 7-fold elevated VTE
risk, and in some cancer types the risk is 28-fold higher.
The research team assessed over eight million women years of observation and during this period there were 4,246 first episodes of VTE
Overall, antipsychotic users had a 32% greater risk of VTE
than did nonusers.
Through newly developed Gulf Thrombosis Collaboration (GTC) guidelines for the management of VTE
, delegates were shown how better risk assessment models and improved recommendations would now lead to the more complete identification of patients at risk.
Cohen, et al, the researchers determined that in only 40 percent of medical patients who were at risk for VTE
and only 60 percent of surgical patients at risk for VTE
received prophylactic treatment with Heparin or a low molecular weight Heparin (LMWH) injection.
Comment: The results of this study indicate that supplementation with vitamin E can reduce the risk of VTE
AVE5026 20 mg and 40 mg showed a superior efficacy for confirmed adjudicated VTE
with a good safety profile.