VapBVirulence Associated Protein B (pathogenicity)
VapBVirginia Associated Press Broadcasters
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Abbreviations SOD1: Superoxide dismutase 1 ALS2: Alsin SETX: Senataxin SPG11: Spastic paraplegia 11 FUS: Fused in sarcoma RNA binding protein VAMP: Vesicle-associated membrane protein VAPB: Associated protein B and C ANG: Angiogenin TARDBP: TAR DNA-binding protein FIG4: FIG4 phosphoinositide 5-phosphatase OPTN: Optineurin ATXN2: Ataxin-2 C9ORF72: Chromosome 9 open reading frame 72 VEGF: Vascular endothelial growth factor IFN-[gamma]: Interferon gamma TNF-[alpha]: Tumor necrosis factor ILs: Interleukins IL-1[beta]: Interleukin 1 beta UBC: Ubiquitin C TBK1: TANK-binding kinase 1 SQSTM1: Sequestosome 1 DCTN1: Dynactin subunit 1 IMPAS-1: Histocompatibility minor 13.
Silva et al., "A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis," The American Journal of Human Genetics, vol.
equi isoladas de humanos e suinos frequentemente possuem uma proteina de superficie muito semelhante a VapA, denominada VapB (BYRNE et al., 2001).
Pathogenicity of Rhodococcus equi expressing a virulence-associated 20kDa protein (VapB) in foals.
"The VAPB protein is involved in many cellular processes, so it seems likely it contributes to the pathogenesis of other forms of ALS," Muotri said.
[Source :RefSeq mRNA;Acc:NM_214115] ENSSSCG00000007514 Sus scrofa VAMP (vesicle-associated membrane protein)-associated protein B and C (VAPB), mRNA.