'It may seem wery strange talkin' to me about these here affairs, miss,' said Sam, with great vehemence; 'but all I can say is, that I'm not only ready but villin
' to do anythin' as'll make matters agreeable; and if chuckin' either o' them sawboneses out o' winder 'ull do it, I'm the man.' As Sam Weller said this, he tucked up his wristbands, at the imminent hazard of falling off the wall in so doing, to intimate his readiness to set to work immediately.
and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion," American Journal of Physiology-Renal Physiology, vol.
Immunohistochemical staining was positive for CDX2, CK7, CK20, and villin
. There was no loss of expression of MLH1, MSH2, and MSH6, suggesting intact proteins.
Diabetic Nephropathy Associated with a Decrease in Brush Border Villin
Levels in Meprin Expressing Kidneys.
The expression of CDX2 introduces a potential diagnostic pitfall since ITAC most often demonstrates an intestinal immunophenotype (negative for CK7, positive for CDX2, CK20, and villin
), whereas non-ITACs are consistently positive for CK7 and expected to be negative for CK20 and CDX2 .
A number of immunomarkers have been tested in this regard, which include CK7, CK20, CDX2, villin
, thrombomodulin, [alpha]-methylacyl coenzyme-A racemase, carcinoembryonic antigen (CEA), GATA3, p63, CDH17, bcatenin, and many others.
and Ki-67 indicate the hepatic origin and cellular proliferation extent, respectively, and support the HCC diagnosis, although AFP is negatively stained.
The tumour cells were negative for ER, PR, CK20, villin
, and GCDFP-15.
is a structural component of microvilli forming the brush border of the small intestine and plays a key role in maintaining brush border organization by binding to F-actin in a network of filaments (24).
Shigella flexneri infection is dependent on villin
in the mouse intestine and in primary cultures of intestinal epithelial cells.
severing activity enhances actin-based motility in vivo.
For example, Fullbeck et al (59) used SuperMimic software in order to be able to present folding of the 35-residue subdomain (H35) at its C-terminus of the villin
headpiece by irradiation, to replace parts of its main chain without changing the overall structure of the subdomain.