VDSS

(redirected from Volume of Distribution at Steady State)
AcronymDefinition
VDSSVirginia Department of Social Services
VDSSVolume of Distribution at Steady State
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Human IgG has larger clearance (a), lower mean residence time (MRT, (b)), larger volume of distribution at steady state ([V.sub.ss], (c)), and lower half-life (d) when it is administered at the end of gestation (GD65 [+ or -] 2) compared to nonpregnant animals; data shown as mean [+ or -] SEM, < 0.05 (Student's f-test).
PK parameters 3.5 mg/kg dose (Mean [+ or -] SD) Control (n = 5) Pregnant (n = 5) AUC ([micro][g*hr/mL) 8690 [+ or -] 2418 3563 [+ or -] 2500 CL (mL/hr per kg) 0.4 [+ or -] 0.2 1.4 [+ or -] 0.9 Half-life (hours) 107 [+ or -] 24 108 [+ or -] 40 MRT (hours) 53 [+ or -] 4 35 [+ or -] 15 [V.sub.ss] (mL/kg) 23 [+ or -] 9 41 [+ or -] 11 PK parameters 7.0 mg/kg dose (Mean [+ or -] SD) Control (n = 5) Pregnant (n = 5) AUC ([micro][g*hr/mL) 12522 [+ or -] 3309 8100 [+ or -] 2393 CL (mL/hr per kg) 0.6 [+ or -] 0.2 1 [+ or -] 0.4 Half-life (hours) 114 [+ or -] 58 60 [+ or -] 23 MRT (hours) 46 [+ or -] 4 35 [+ or -] 14 [V.sub.ss] (mL/kg) 27 [+ or -] 6 30 [+ or -] 5 AUC: area under the curve; CL: clearance; MRT: mean residence time; [V.sub.ss]: volume of distribution at steady state.