Except for the marginal reduction effect in postmenstrual phase determined between the 3rd and the 6th cycles, DRSP group showed significant reduction in mean WHAQ scores of all thethreephasesatthe3rdandthe6thcycles,whileDSG group showed significant reduction in menstrual phase and premenstrual phase at the 6th cycle between the 3rd and the 6th cycles and postmenstrual phase between the 3rd and the 6th cycles.
WHAQ score could range from 0 to the maximal score of 92.
This study demonstrated the main result in which low-dose COC containing DRSP reduced the premenstrual symptoms as measured by WHAQ, and it provides good contraceptive efficacy consistent with the previous studies [17, 18].
Using ANCOVA model which limits the potential errors resulting from uneven baseline parameters between groups, even at the baseline, self-report showed nonsignificant higher mean WHAQ score, and low-dose COC containing DRSP seemed to be more efficient than low-dose COC containing DSG regarding the premenstrual symptoms along the study period of 6 cycles.
Second, the main outcome and the average WHAQ scores were rather subjective and based on the recent memory that might be affected by several factors.