WMLA Total Present Absent Number (% of total) 72 18 (25) 54 (75) Age (SD) 71.9 (7.0) 74.6 (6.5) 70.8 (7.0) Male/female 37/35 8/10 29/25 Mean MMSE score (SD) 14.7 (6.5) 13.5 (7.2) 15.1 (6.3)
WMLA, white matter low attenuation; MMSE, Mini-Mental State Examination.
In patients with no WMLA, 12 patients (31%) who tolerated the treatment were classified as responders, compared with two out of seven (28.5%) in the group with WMLA.
(and %) of patients MMSE score after 3 months With WMLA (n = 7) Same or better 5 (71%) Improved by by [is greater than or equal to] 1 points 4 (57%) by [is greater than or equal to] 2 points 3 (43%) by [is greater than or equal to] 3 points 2 (28.5%) by [is greater than or equal to] 4 points 1 (14%) MMSE score after 3 months Without WMLA (n = 39) Same or better 21 (54%) Improved by by [is greater than or equal to] 1 points 18 (46%) by [is greater than or equal to] 2 points 16 (41%) by [is greater than or equal to] 3 points 12 (31%) by [is greater than or equal to] 4 points 8 (20.5%)
Table 1 Demographic characteristics of patients with and without WMLA
Comparing neuropsychological performance in patients with and without WMLA revealed that patients with WMLA performed worse on most tests compared with those without white matter lesions (Table II).
Difference in cognitive performance between patients with and without WMLA
As can be seen from Table III, patients with extensive WMLA, i.e.
The extent of WMLA was recorded on a four-point scale (from 0 to 3) where 0 = no visible WMLA, 1 = WMLA localized to the frontal and/or occipital periventricular regions of the lateral ventricles, 2 = as in 1 but WMLA spreading towards the centrum semiovale, and 3 = extensive WMLA coalescing with the centrum semiovale.
One hundred patients (49.5%), with a mean age of 74.5 years (SD 8.4), had visible WMLA on their brain CTs, compared with the 102 patients (55.5%), with a mean age of 67.5 years (SD 10.6) with no visible WMLA.
Table II shows that the prevalence of WMLA increases from 12% in patients who had no evidence of a cementing illness, to 32% in those with isolated memory loss and 59% in patients suffering from possible or probable dementia.
Number (%) of patients in the different diagnostic groups and the incidence of WMLA No.