The least squares (ls) mean change from baseline in WOMAC
pain scores were -2.24 for placebo, -2.70 for tanezumab 2.5 mg, and -2.85 for tanezumab 5 mg (P less than or equal to .01 and P less than or equal to .001 vs.
The co-primary efficacy endpoints evaluated changes from baseline to week 16 in the WOMAC
Pain subscale, the WOMAC
Physical Function subscale, and the Patient's Global Assessment of OA.
In this study, significant changes were observed both in the ROM and in WOMAC
Improvement in pain was also compared on VAS and WOMAC
is standardized questionnaire to evaluate the condition of the participants who were suffering from OA of the knee joint.
The primary endpoints for this trial were safely and knee-related pain, stiffness and function measured using the Western Ontario and McMaster Universities (WOMAC
) osteoarthritis index questionnaire.
involves a set of questions, which are used to evaluate the clinical condition of patients with knee and hip OA including levels of pain, stiffness, and physical function in the joints.
Variables: La funcionalidad se midio con el cuestionario de OA de las Universidades de Western Ontario y McMaster (WOMAC
) (Bellamy et al., 1988), el que fue disenado para medir dolor, rigidez y capacidad funcional a nivel de cadera y rodilla, que presentan osteoartritis.
As the KL grade is an ordinal result, linear regression in univariant and multivariant ways (after adjusting for age, sex, BMI, and WOMAC
scores) was performed to evaluate the association between IL-34 levels and KL grades.
Discussion: Larger, randomized control trials are needed on each of these therapies using more standardized protocols and more objective variables in addition to the self-reported WOMAC
pain scale, for example, range-of-motion and observed range-of-motion pain.
Correlation analysis between the painDETECT scores and age, BMI, disease duration, VAS, and WOMAC
scores were performed with Spearman correlation test.