WTIPWarning; This Is Propaganda (magazine; UK)
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Two WT1-associated proteins, WT1-interacting protein (WTIP) and brain acid-soluble protein 1, function as cofactors in WT1 transcriptional activity.
Experimental evidence suggests that more than one mechanism may disrupt the integrity of the SD and podocyte phenotype, including (1) genetically determined mutations in genes directly encoding for SD proteins, (25,26) (2) modulation of the conformation of the SD by WTIP through interaction with CD2AP, (5) (3) nuclear relocation of SD proteins, such as nephrin and the CD2AP-binding protein dendrin, and induction of TGF-[beta]-mediated apoptosis, (32) and (4) modulation of the integrity of the SD by external forces challenging podocytes, as may occur in hyperfiltration-mediated FSGS33 (discussed below).