Included among those with publicly reported whole-genome analysis
are James Watson and Craig Venter, both Ph.D.
Specific topics include the statistical design and interpretation of microarray experiments; whole-genome analysis
of cancer; bioinformatics approaches to the analysis of the transcriptome of animal models of cancer; significance of aberrant expression of miRNAs in cancer cells; proteomic methods in cancer research; comprehensive genomic profiling for biomarker discovery for cancer detection, diagnostics, and prognostics; gene expression profiling of the leukemias; personalized medicine in the clinical management of colorectal cancer; and PIK3CA gene alterations in human cancers.
"The combination of these MegAllele brand reagents with our industry-standard GeneChip brand microarrays will give customers real solutions for candidate gene analysis and custom genotyping, adding to our growing portfolio of DNA analysis products that range from whole-genome analysis
"The combination of these MegAllele(TM) brand reagents with our industry-standard GeneChip brand microarrays will give customers real solutions for candidate gene analysis and custom genotyping, adding to our growing portfolio of DNA analysis products that range from whole-genome analysis
Our results, based on the whole-genome analysis
, showed that the Myanmar H9N2 viruses possessed all genetic signatures and virulence determinants similar to avian and human H9N2 viruses circulating in China in 2015 (online Technical Appendix Tables 3-5).
mitis strains has been observed previously in sequencing and DNA:DNA hybridization studies and meant that we could not use whole-genome analysis of single-nucleotide polymorphisms to determine strain relatedness (30,31).
In addition to the capsule operons, multiple other comparisons arising from our whole-genome analysis confirmed the idea that the 4 cluster 2 strains and strain SVGS003 were closely related.
mitis cluster 2; strain SVGS003, a group 3 strain by MLSA, appears to have genetic characteristics of the cluster 2 strains by whole-genome analysis.
cholerae isolates from clinical infections, attributed to geographically distinct locations and sharing PFGE fingerprints with Haiti outbreak strains, from the PulseNet USA database for comparative whole-genome analysis
. Although detailed epidemiologic investigations are essential for unequivocally attributing geographic origin(s) and means of cholera introduction into Haiti, genome sequences of these 23 contemporary isolates showed details related to genetic content and diversity that were otherwise missed with lower-resolution PFGE subtyping, thereby providing useful genetic ancestry information for interpreting the outbreak in Haiti.
Altogether, these new findings underscore the importance of rapid, whole-genome analysis for future influenza surveillance (28).
Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses.