X-ALD

Acronym	Definition
X-ALD	X-Linked Adrenoleukodystrophy (disease)

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X-linked adrenoleukodystrophy (X-ALD) affects 1 in 17,000 people worldwide.

NeuroVia begins Phase 1/2 clinical study of lead drug candidate NV1205 for childhood cerebral adrenoleukodystrophy treatment

X-ALD is a monogenic disease, with an incidence ranging from 1:20000 to 1:100000, which is caused by mutations in the ABCD1 (ATP binding cassette subfamily D member 1) gene, located on Xq28.

Challenges for worldwide harmonization of newborn screening programs

In X-ALD, since cholesterol is entrapped as esters in the lamellar inclusions, it cannot be normally metabolized into T.

Testosterone-induced effects on lipids and inflammation

Pentoxifylline, a methylxanthine inhibiting the activity of tumor necrosis factor [alpha] (TNF[alpha]), an important component in the X-ALD inflammatory response, has been recently used in the treatment of X-ALD.

Uncommon cause of acute adrenal failure/Akut surrenal yetersizliginin seyrek rastlanan bir nedeni

Do you remember the 1992 motion picture Lorenzo's Oil, which starred Nick Nolte and Susan Sarandon, about a boy who develops the rare and often deadly disease X-ALD? Fourteen years after the release of that film, Dr.

News about newborn screening

(NASDAQ: VKTX) has released positive results from a 25-week proof-of-concept study of VK0214 in an in vivo model of X-linked adrenoleukodystrophy (X-ALD), the company said.

Viking Therapeutics Study of VK0214 in Mouse Model of X-ALD Demonstrates Significant Reductions in Plasma and Tissue VLCFAs

Fibroblasts from healthy controls and patients with X-ALD were cultured in the absence or presence of 20 [micro]mol/L [D.sub.3]-C24:0 in HAM-F10 tissue culture medium supplemented with 100 mL/L fetal calf serum, penicillin (100 IU/mL), streptomycin (100 IU/mL), and glutamine (2 mmol/L).

Method for measurement of peroxisomal very-long-chain fatty acid ([beta]-oxidation in human skin fibroblasts using stable-isotope-labeled tetracosanoic acid

With no curative treatment currently available, there exists an unmet medical need for a therapeutic benefit for X-ALD patients.

Bradbury, Kaye Named to NeuroVia Board of Directors

M2 PHARMA-July 21, 2017-NeuroVia Closes USD 14m Series A Financing Round; Will Fund X-ALD Disease Treatment

NeuroVia Closes USD 14m Series A Financing Round; Will Fund X-ALD Disease Treatment