X-ALD

AcronymDefinition
X-ALDX-Linked Adrenoleukodystrophy (disease)
References in periodicals archive ?
Plasma VLCFA levels were determined by measuring unsaturated lysophosphatidylcholine fatty acid esters, which are biomarkers for VLCFAs in X-ALD.
This mechanism has been demonstrated to affect the expression of the genes that are relevant to the manifestation of X-ALD.
Viking Therapeutics Study of VK0214 in Mouse Model of X-ALD Demonstrates Significant Reductions in Plasma and Tissue VLCFAs
A main issue in moving towards universal NBS for X-ALD will be the establishment of protocols for follow-up counseling of positive screens.
Recent pilot programs for SCD, LSDs and X-ALD have provided further evidence to support the inclusion of these disorders in expanded NBS strategies.
Challenges for worldwide harmonization of newborn screening programs
Pentoxifylline, a methylxanthine inhibiting the activity of tumor necrosis factor [alpha] (TNF[alpha]), an important component in the X-ALD inflammatory response, has been recently used in the treatment of X-ALD.
The recent isolation of the X-ALD gene raises the hope of gene therapy in the future.
Uncommon cause of acute adrenal failure/Akut surrenal yetersizliginin seyrek rastlanan bir nedeni
His screening discovery truly signals the beginning of the end of this devastating pediatric disorder, because it means boys born with the defective gene that leads to X-ALD can be identified at birth and can then take advantage of preventive treatments, such as Lorenzo's Oil, before symptom onset puts them past the window of opportunity to be saved.
Moser is spearheading efforts to incorporate screening for X-ALD in the slate of newborn screening tests most babies receive before they leave the hospital.
News about newborn screening
NeuroVia is focused on addressing unmet medical needs in neurological diseases with the primary goal to arrest the onset of devastating neurological deficits associated with X-ALD.
Bradbury, Kaye Named to NeuroVia Board of Directors
3]-C24:0 in fibroblasts from healthy individuals and patients with X-ALD is shown in Fig.
3]-C24:0 of fibroblasts from controls and patients with different peroxisomal ([beta]-oxidation disorders, including X-ALD, AOX deficiency, and DBP deficiency, are summarized in Table 1.
Method for measurement of peroxisomal very-long-chain fatty acid ([beta]-oxidation in human skin fibroblasts using stable-isotope-labeled tetracosanoic acid
X-ALD is characterised by elevated levels of very long chain fatty acids (VLCFAs) in various tissues due to any of a number of loss-of-function mutations in the ABCD1 gene.
NeuroVia Closes USD 14m Series A Financing Round; Will Fund X-ALD Disease Treatment
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