(2013) Disease-causing mutations in the
XIAP BIR2 domain impair NOD2-dependent immune signalling.
AEG35156 (Aegera Therapeutics),
XIAP mRNA ifadesini engelleyen bir antisens molekuldur.
Low
XIAP protein expression was observed in the compact bone layer of the tibia between the studied groups p=0, Kruskal-Wallis test.
The interaction sites of
XIAP were mapped to the N-terminal, SAH and DDHR domains of Siva-1 (12).
indicated that sulforaphane, an active compound in cruciferous vegetables, synergistically inhibits self-renewal capacity of pancreatic cancer stem cells with quercetin, a major polyphenol and flavonoid commonly detected in many fruits and vegetables, by inhibiting the expression of Nanog, phosphorylation of FKHR, Bcl-2,
XIAP, activating caspase-3, and proteins involved in the epithelial-mesenchymal transition (beta-catenin, twist-1, ZEB1, and vimentin) [46].
Wu et al (56) studied the expression of
XIAP in 13 cases of mesothelial hyperplasia and 31 MMs.
Bcl2: B-cell lymphoma 2; DNA: deoxyribonucleic acid; Grp78: glucose-related protein 78; Hsp75: heat shock protein 75; iNOS: inducible nitric oxide synthase; Mcl1: myeloid cell leukemia 1; NF-[kappa]B: nuclear factor kappa B; PUMA: p53 upregulated modulator of apoptosis; TLR4: Toll-like receptor 4; TNF-[alpha]: tumor necrosis factor-alpha; VDAC1: voltage-dependent anion channel 1;
XIAP: X-linked inhibitor of apoptosis protein.
Kim, "Ciglitazone induces caspase-independent apoptosis through down-regulation of
XIAP and survivin in human glioma cells," Neurochemical Research, vol.
A histone deacetylase inhibitor LBH589 down regulates
XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL.
Finally, using CH-induced lipid peroxidation, we found that a unique eEF2 posttranslational modified derivative of histidine (H715) known as diphthamide plays a role in the protection of cells against the degradation of eEF2, and it is important to control the translation of IRES-dependent proteins
XIAP and FGF2, two proteins that promote cell survival under conditions of oxidative stress [380].
(18) At least 3 classes of IAPs composed of a total of 8 proteins have been identified in humans including the best known cIAP1, cIAP2, and
XIAP. (19) Overexpression of IAPs has been found in a wide variety of cancer cell lines and primary tumor samples.
(61) For antiapoptotic activity, increased expression of Bax, cIAP-1/2,
XIAP, Smac/Diablo, and survivin has been suggested to be associated with p38 MAPK activation in some cell line models.