XIAP

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Related to XIAP: Inhibitor of Apoptosis Protein 1

Acronym	Definition
XIAP	X-linked Inhibitor of Apoptosis

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(2013) Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.

Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders

AEG35156 (Aegera Therapeutics), XIAP mRNA ifadesini engelleyen bir antisens molekuldur.

Prostat Kanseri Tedavisinin Gelecegi Apoptotik indukleyicilerde mi?/Does the Future of Prostate Cancer Treatment Lie with Apoptotic Inducers?

Low XIAP protein expression was observed in the compact bone layer of the tibia between the studied groups p=0, Kruskal-Wallis test.

Apoptosis in Bone Defect of Diabetic Rats Treated with Low Intensity Laser: Radiological and Immunohistochemical Approach/Apoptosis en Ratones Diabeticos con Defecto Oseo Tratados con Laser de Baja Intensidad: Evaluacion Radiologica e Inmunohistoquimica

The interaction sites of XIAP were mapped to the N-terminal, SAH and DDHR domains of Siva-1 (12).

The N-terminal 33 amino acid domain of Siva-1 is sufficient for nuclear localization

indicated that sulforaphane, an active compound in cruciferous vegetables, synergistically inhibits self-renewal capacity of pancreatic cancer stem cells with quercetin, a major polyphenol and flavonoid commonly detected in many fruits and vegetables, by inhibiting the expression of Nanog, phosphorylation of FKHR, Bcl-2, XIAP, activating caspase-3, and proteins involved in the epithelial-mesenchymal transition (beta-catenin, twist-1, ZEB1, and vimentin) [46].

Natural Products as Adjunctive Treatment for Pancreatic Cancer: Recent Trends and Advancements

Wu et al (56) studied the expression of XIAP in 13 cases of mesothelial hyperplasia and 31 MMs.

Epithelioid lesions of the serosa

Bcl2: B-cell lymphoma 2; DNA: deoxyribonucleic acid; Grp78: glucose-related protein 78; Hsp75: heat shock protein 75; iNOS: inducible nitric oxide synthase; Mcl1: myeloid cell leukemia 1; NF-[kappa]B: nuclear factor kappa B; PUMA: p53 upregulated modulator of apoptosis; TLR4: Toll-like receptor 4; TNF-[alpha]: tumor necrosis factor-alpha; VDAC1: voltage-dependent anion channel 1; XIAP: X-linked inhibitor of apoptosis protein.

Targeting Glial Mitochondrial Function for Protection from Cerebral Ischemia: Relevance, Mechanisms, and the Role of MicroRNAs

Kim, "Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells," Neurochemical Research, vol.

Combination Treatment with PPAR[gamma] Ligand and Its Specific Inhibitor GW9662 Downregulates BIS and 14-3-3 Gamma, Inhibiting Stem-Like Properties in Glioblastoma Cells

A histone deacetylase inhibitor LBH589 down regulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL.

Molecular changes in Mesothelioma with an impact on prognosis and treatment

Finally, using CH-induced lipid peroxidation, we found that a unique eEF2 posttranslational modified derivative of histidine (H715) known as diphthamide plays a role in the protection of cells against the degradation of eEF2, and it is important to control the translation of IRES-dependent proteins XIAP and FGF2, two proteins that promote cell survival under conditions of oxidative stress [380].

Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal

(18) At least 3 classes of IAPs composed of a total of 8 proteins have been identified in humans including the best known cIAP1, cIAP2, and XIAP. (19) Overexpression of IAPs has been found in a wide variety of cancer cell lines and primary tumor samples.

Expression of AIF and HtrA2/Omi in small lymphocytic lymphoma and diffuse large B-cell lymphoma

(61) For antiapoptotic activity, increased expression of Bax, cIAP-1/2, XIAP, Smac/Diablo, and survivin has been suggested to be associated with p38 MAPK activation in some cell line models.