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XIAPX-linked Inhibitor of Apoptosis
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2013) Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.
Recently, another report in line with the above result found that Siva-1 could balance NF-[kappa]B and JNK signaling to promote apoptosis by physically interacting with XIAP and TAK/TAB1 to form a complex.
To further confirm that caspases were activated in EBV-induced apoptosis, we assessed XIAP expression.
When XIAP is left holding NO, the result is a double whammy for brain cells, since cells are programmed to self-destruct when either XIAP has NO attached to it or when caspases don't.
2007), mientras que las proteinas Smac/Diablo y HtrA2/Om promueven apoptosis por inhibicion de IAP (inhibidores de proteinas apoptoticas) como cIAP1, cIAP2 y XIAP (Elmore, 2007; Huerta et al.
Como ya mencionamos, Smac/DIABLO, puede liberar a las procaspasas de la influencia inhibidora de las IAP, como XIAP (proteina inhibidora de apoptosis ligada al X), CIAP1 (proteina inhibidora de apoptosis celular 1), CIAP2 (proteina inhibidora de apoptosis celular 2) y NIAP (proteina inhibidora de apoptosis neuronal), para que sean activadas por auto catalisis.
Aegera's lead oncology product is a XIAP antisense therapeutic, AEG35156, developed in collaboration with Hybridon, Inc.
Other researchers have identified compounds that prevent XIAP from inhibiting some of the caspases.
Discovery of potent dual inhibitors of both XIAP and cIAP1 using fragment based drug discovery
Takahashi, "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death," Molecular Cell, vol.
One example with exome sequencing was the identification of a pathogenic variant in XIAP in a 15-month-old patient with life-threatening inflammatory bowel disease (10).