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XIAPX-linked Inhibitor of Apoptosis
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(2013) Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.
The interaction sites of XIAP were mapped to the N-terminal, SAH and DDHR domains of Siva-1 (12).
indicated that sulforaphane, an active compound in cruciferous vegetables, synergistically inhibits self-renewal capacity of pancreatic cancer stem cells with quercetin, a major polyphenol and flavonoid commonly detected in many fruits and vegetables, by inhibiting the expression of Nanog, phosphorylation of FKHR, Bcl-2, XIAP, activating caspase-3, and proteins involved in the epithelial-mesenchymal transition (beta-catenin, twist-1, ZEB1, and vimentin) [46].
Wu et al (56) studied the expression of XIAP in 13 cases of mesothelial hyperplasia and 31 MMs.
Bcl2: B-cell lymphoma 2; DNA: deoxyribonucleic acid; Grp78: glucose-related protein 78; Hsp75: heat shock protein 75; iNOS: inducible nitric oxide synthase; Mcl1: myeloid cell leukemia 1; NF-[kappa]B: nuclear factor kappa B; PUMA: p53 upregulated modulator of apoptosis; TLR4: Toll-like receptor 4; TNF-[alpha]: tumor necrosis factor-alpha; VDAC1: voltage-dependent anion channel 1; XIAP: X-linked inhibitor of apoptosis protein.
Kim, "Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells," Neurochemical Research, vol.
A histone deacetylase inhibitor LBH589 down regulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL.
Finally, using CH-induced lipid peroxidation, we found that a unique eEF2 posttranslational modified derivative of histidine (H715) known as diphthamide plays a role in the protection of cells against the degradation of eEF2, and it is important to control the translation of IRES-dependent proteins XIAP and FGF2, two proteins that promote cell survival under conditions of oxidative stress [380].
(18) At least 3 classes of IAPs composed of a total of 8 proteins have been identified in humans including the best known cIAP1, cIAP2, and XIAP. (19) Overexpression of IAPs has been found in a wide variety of cancer cell lines and primary tumor samples.
(61) For antiapoptotic activity, increased expression of Bax, cIAP-1/2, XIAP, Smac/Diablo, and survivin has been suggested to be associated with p38 MAPK activation in some cell line models.