XIAP

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Related to XIAP: Inhibitor of Apoptosis Protein 1

Acronym	Definition
XIAP	X-linked Inhibitor of Apoptosis

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References in periodicals archive ?

2013) Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.

Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders

Recently, another report in line with the above result found that Siva-1 could balance NF-[kappa]B and JNK signaling to promote apoptosis by physically interacting with XIAP and TAK/TAB1 to form a complex.

The N-terminal 33 amino acid domain of Siva-1 is sufficient for nuclear localization

To further confirm that caspases were activated in EBV-induced apoptosis, we assessed XIAP expression.

Effects of Epstein-Barr virus on the development of dendritic cells derived from cord blood monocytes: an essential role for apoptosis

When XIAP is left holding NO, the result is a double whammy for brain cells, since cells are programmed to self-destruct when either XIAP has NO attached to it or when caspases don't.

New clues about cause of brain cell death in Parkinson's, Alzheimer's

2007), mientras que las proteinas Smac/Diablo y HtrA2/Om promueven apoptosis por inhibicion de IAP (inhibidores de proteinas apoptoticas) como cIAP1, cIAP2 y XIAP (Elmore, 2007; Huerta et al.

Tecnicas para la deteccion de apoptosis y senescencia celular in vitro y su importancia en biotecnologia de la salud

Como ya mencionamos, Smac/DIABLO, puede liberar a las procaspasas de la influencia inhibidora de las IAP, como XIAP (proteina inhibidora de apoptosis ligada al X), CIAP1 (proteina inhibidora de apoptosis celular 1), CIAP2 (proteina inhibidora de apoptosis celular 2) y NIAP (proteina inhibidora de apoptosis neuronal), para que sean activadas por auto catalisis.

Neuronal apoptosis: signal and cell diversity/Apoptosis neuronal: la diversidad de senales y de tipos celulares

Aegera's lead oncology product is a XIAP antisense therapeutic, AEG35156, developed in collaboration with Hybridon, Inc.

Aegera adds six patents to their apoptosis patent estate

Other researchers have identified compounds that prevent XIAP from inhibiting some of the caspases.

Compounds trigger tumor-cell suicide

Discovery of potent dual inhibitors of both XIAP and cIAP1 using fragment based drug discovery

Astex Pharmaceuticals to Present at AACR Annual Meeting

Takahashi, "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death," Molecular Cell, vol.

Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease

Regulation of the Apaf-1 /caspase-9 apoptosome by caspase3 and XIAP.

The variable chemotherapeutic response of Malabaricone-A in leukemic and solid tumor cell lines depends on the degree of redox imbalance

One example with exome sequencing was the identification of a pathogenic variant in XIAP in a 15-month-old patient with life-threatening inflammatory bowel disease (10).