Target organism Primer/ Sequence (5;-3;) probe All bacteria Fwd primer ACT CCT ACG GGA GGC AG Rev primer GAC TAC CAG GGT ATC taa tcc (6-FAM)-TGC CAG CAG Probe CCG CGG TAA TAC-(BHQ-1) Clostridium Fwd primer GCA CAA GCA GTG GAGT cluster IV Rev primer CTT CCT CCG TTT TGT CAA (Ruminococcaceae) Probe (6-FAM)-AGG GTT GCG CTC GTT-(BHQ-1) Cluster XIVa
Fwd primer GCA GTG GGG AAT ATT GCA Rev primer CTT TGA GTT TCA TTC TTG CGA A Probe (6-FAM)-AAA TGA CGG TAC CTG ACT AA-(BHQ-1) Bacteroidetes Fwd primer GAG AGG AAG GTC CCC CAC Rev primer CGC TAC TTG GCT GGT TCAG Probe (6-FAM)-CCA TTG ACC AAT ATT CCT CAC TGC TGC CT-(BHQ-1) Bifidobacterium Fwd primer GCG TGC TTA ACA CAT GCA AGT C spp.
Specific populations of commensal bacteria, for example, Bacteroides fragilis, Bifidobacterium infantis, and Clostridium clusters IV and XIVa
, also induce the so-called regulatory T cells (Tregs), a subset of forkhead box P3 positive ([FoxP3.sup.+]) [CD4.sup.+] T-helper lymphocytes that maintain gut homeostasis by stimulating the production of anti-inflammatory cytokine
Dr Honda's work shows that compositions of bacterial strains belonging to Clostridium clusters IV and/or XIVa
may potentially be used to treat a range of diseases including infectious, allergic and autoimmune diseases.
Honda's work provides an avenue for the treatment of a variety of diseases including immune and infectious diseases employing bacterial strains belonging to Clostridium clusters IV and/or XIVa
. Clostridium bacteria include a variety of spore-forming species that can abundantly colonize the gut.
lavalense 16S rRNA gene sequence belongs to the Clostridium coccoides rRNA group, the rRNA cluster XIVa
of the genus Clostridium .
HONG KONG, May 20, 2015 - (ACN Newswire) - This announcement is made by Winshine Entertainment & Media Holding Company Limited (the "Company", together with its subsidiaries, the "Group") pursuant to Rule 13.09 of the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited (the "Listing Rules") and the Inside Information Provisions under Part XIVA
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The microbiota, and in particular members of the Clostridium clusters IV and XIVa
, now also known as Ruminococcaceae and Lachnospiraceae, produce the SCFA butyrate as a metabolite [103, 104].
Particularly, the relative proportion of Clostridium cluster XIVa
increased by 20% in feces after FMT.
The most commensal bacteria present in human fecal flora are represented by two main groups of Firmicutes, subdivided in Clostridium coccoides (Clostridium cluster XIVa
) and Clostridium leptum (Clostridium cluster IV) that are butyrate producers, and by the group of the Cytophaga-Flavobacterium-Bacteroides (CFB) [3, 4].
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