The xanthine oxidase
inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung.
It concluded that inhibition of xanthine oxidase
by oxypurinol in heart failure patients improved left ventricle ejection fraction (LVEF) in patients with LVEF less than or equal to 40% after 1 month of treatment.24 The findings in the current study are parallel with the results of the cited trial24 and means that the reduction in reactive oxygen species with allopurinol can have favourable effects on cardiac hypertrophy without the requirement of reducing blood pressure.
Guidelines recommend a xanthine oxidase
inhibitor as first-line therapy.
: Isolation, assays of activity, and inhibition.
The xanthine oxidase
inhibitory activities of S-substituted perhalonitrobuta-1,3-diene compounds were given in Table 1.
Hashimoto, "A new spectrophotometric assay method of xanthine oxidase
in crude tissue homogenate," Analytical Biochemistry, vol.
Role of urate, xanthine oxidase
and the effects of allopurinol in vascular oxidative stress.
Uric acid levels can be decreased by using allopurinol, a xanthine oxidase
Slight fluctuations were detected in mean nitric oxide, prostaglandin E2, prostaglandin F2-alpha, superoxide dismutase, glutathione peroxidase, malondialdehyde, alginate dialdehyde, and xanthine oxidase
levels; however, the differences were not significant (p>0.05, Table 1).
A natural agent with the power to safely inhibit production of xanthine oxidase
would mark a big advance in the quest to reverse high uric acid levels without side effects.
d) Tumour lysis syndrome can be prevented with hydration and direct xanthine oxidase
Alkylation and acetylation of phenolic groups at positions C-5, C-7, and C-8 (i.e., methoxy or acetate groups) were found to decrease the antioxidant and scavenging activities as observed from the result of DPPH radical scavenging assay, FRAP assay, and xanthine oxidase
inhibitory assay of semisynthesized wogonin and norwogonin analogs.