However, activation of Yapl also caused the mice to develop squamous-cell carcinoma-like tumors, the researchers found.
They further showed that Yapl is inactivated by a known tumor suppressor called alpha-catenin, which binds to Yapl and keeps it outside the cell nucleus.
Our work suggests that over-activation of Yapl is likely what drives these cancers."
"Through Yapl, alpha-catenin tells epidermal stem cells to either proliferate or not proliferate, depending on the needs of the tissue," Camargo said.
Camargo's group is conducting screening tests to find small molecules that mimic Yapl, to induce skin regeneration at the site of a wound, or that inhibit Yapl to treat skin tumors.
CRISIL believes that YAPL will continue to benefit over the medium term from its long standing presence in the auto dealership business.
YAPL has also received approval from TML for passenger car dealerships in Mirzapur and Badohi; they are expected to be operational by March 2011.
YAPL reported a profit after tax (PAT) of Rs.6.1 million on net sales of Rs.1092 for 2009-10 (refers to financial year, April 1 to March 31), as against a PAT of Rs.0.2 million on net sales of Rs.