References in periodicals archive ?
YMJ extract was dissolved in distilled water for injection (Choong-Wae Pharmaceutical, Ltd., Korea) and administered by oral gavage at doses of 0, 500, 1000, and 2000 mg/kg/day for 4 weeks.
Cytotoxic effects of YMJ against the cell lines were measured using a3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay as described .
In both male and female rats treated with YMJ, there were no significant differences in body weight between vehicle control and YJM-treated groups (Figure 2).
Cytotoxicity of YMJ was evaluated against 23 different cell lines.
YMJ is a well-known herbal formula that has long been used in CAM for the treatment of renal diseases and diabetes mellitus.
Given the efficacy of YMJ, information on its safety as a medicine should be evaluated carefully because YMJ is a mixture of six different herbs as well as several different phytochemicals.
We observed that YMJ did not significantly change clinical signs, body weight, or food intake in either male or female rats.
In terms of hematological data, YMJ administration significantly decreased the PT at 1000 and 2000 mg/kg/day after female rats.
Thus, 4-week repeated oral administration of YMJ caused no subacute toxic effects in rats.
Furthermore, we tested the cytotoxicity of YMJ against 23 different cell lines (Table 9).
In conclusion, our findings provide information on the safety of YMJ in vitro and in vivo.
Acronyms browser ?
Full browser ?