YPTOYoung Professionals of Toronto (Canada)
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Clinical Chemotherapy and Outcome pCR rate pCR rate Refe- trial HER2-targeted HR+/HER2+ HR-/HER2+ rence agents Docetaxel NeoSphere Carboplatin ypT0 20.0% 36.8% [32] Trastuzumab (a) Docetaxel Carboplatin Trastuzumab ypT0 26.0% 63.2% [32] Pertuzumab Paclitaxel NeoALTO Lapatinib ypT0 41.6% 61.3% [33] Trastuzumab Doxorubicin Paclitaxel NOAH Cyclophosphamide ypTO [12] Methotrexate ypN0 51.2% [12] Fluorouracil (b) Trastuzumab 5-fluorouracil Epirubicin ACOSOG Cyclophosphamide ypT0 47.6% 70.4% [34] Z1041 Paclitaxel Trastuzumab (a)--ypT0: pathologic complete response in the breast (absence of invasive neoplastic cells); (b)--ypN0: pathologic complete response in the axillary lymph nodes (absence of invasive neoplastic cells).