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ZAP70Zeta-Chain-Associated Protein Kinase
References in periodicals archive ?
Park, "SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells," FEBS Letters, vol.
As it is occasionally rather hard to determine the mutational status of the IGHV gene, several studies sought to identify new promising surrogate markers, such as ZAP70 and CD38 [49, 50].
It was tested on 32 protein kinases for determination of inhibitory profile and has been shown to inhibit EGF-R, FGF-R1, IGF1-R, INS-R, VEGF-R1, VEGF-R2, VEGF-R3, Syk, ZAP70, PDK1, Yes, and Src(h) [7].
The following genes were studied: CD3[epsilon] molecule, epsilon (CD3-TCR complex) (CD3[epsilon]) (Hs99999153_m1), vav 1 guanine nucleotide exchange factor (VAV1) (Hs00232108_m1), zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70) (Hs_00896347), and lymphocyte-specific protein tyrosine kinase (LCK) (Hs00178427_m1).
More recently, in 2010, investigators proposed a molecular-scoring system based on a combination of tests for the expression of the ZAP70, LPL (lipoprotein lipase), CLLU1 (chronic lymphocytic leukemia upregulated 1), MIR29C (microRNA 29c), and MIR223 (microRNA 223) genes that seemed to predict patient outcomes (6).
For example, CD38 and ZAP70 are poor prognostic markers in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.
Morassi et al., "B-cell subsets in the joint compartments of seropositive and seronegative rheumatoid arthritis (RA) and no-RA arthritides express memory markers and ZAP70 and characterize the aggregate pattern irrespectively of the autoantibody status," Molecular Medicine, vol.
Also, the TRC-MHCII interaction recruits the Zap70 protein to the CD3 coreceptor allowing the activation of the PLC[gamma]-PIP2-PKC[theta] cascade, downstream activation of ERK, and c-Fos expression.
The lymphocytes expressed CD38 antigen but ZAP70 was negative.
All four chemicals up-regulated receptor components (Fcerlg, Tyrobp) in the activation arm of the NK cell signaling pathway, and DEX, DES, and CPS down-regulated additional genes, including Zap70, a protein kinase that serves as a focal point for pathway signaling.