ZEBOVZaire Ebola Virus
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A second group of four macaques was given the treatment after 30 minutes, and on days 1, 2, 3, 4, 5, and 6, after challenge with ZEBOV.
Two of the three animals in the first group (which received four post-exposure treatments) were protected from lethal ZEBOV infection and survived.
To detect filovirus IgG and IgM, we expressed Histagged truncated nucleoproteins from RESTV or ZEBOV in Escherichia coii and used them as antigens (online Technical Appendix).
Of interest, we detected antibodies reacting more strongly to ZEBOV than RESTV nucleoprotein in some filovirus RNA-negative samples, suggesting that the bats were infected with another/other filovirus(es) cross-reactive with ZEBOV nucleoprotein or that nucleoproteins of the novel filoviruses were cross-reactive with ZEBOV and RESTV nucleoproteins.
Genome sequencing identified ZEBOV as the outbreak's causative agent.
The cycle threshold ([C.sub.t]) result from the first EVD PCR whole-blood test at admission was used as a proxy indicator of ZEBOV viral load (i.e., the lower the [C.sub.t], the higher the viral load) (13).
We screened serum samples for IgG against REBOV and ZEBOV by using ELISA and Western blotting at the Commonwealth Scientific and Industrial Research Organisation Australian Animal Health Laboratory Biocontainment Facility (Geelong, Victoria, Australia).
Endpoint titrations with an optical density >3x the background reading were determined for serum samples positive against REBOV and ZEBOV antigens individually.
Initial screening for EBOV antibodies was conducted by using ELISA with a 1:1 mixture of recombinant nucleoprotein (NP) of ZEBOV and Reston EBOV (REBOV).
gambianus bat was positive for both ZEBOV and REBOV.
On the basis of limited data indicating improved survival in rhesus macaques challenged with ZEBOV and treated with rNAPc2, an emergency IND protocol was obtained for using rNAPc2 (25).
Random primed cDNA obtained from cultures of ZEBOV, SEBOV, MARV, YFV isolates from the Gambia and Cote d'Ivoire, RVFV, CCHFV, HTNV, SEOV, and LASV strains Josiah, NL, and AV were subjected to mass tag analysis.