2; Ronquist and Huelsenbeck, 2003) were used to construct a molecular phylogenetic tree based on the comparison of 180 highly conserved amino acid residues that included the most highly conserved middle finger DNA-binding zinc finger domains.
The combination of amino acid sequence identity shared between corresponding zinc finger domains and the structural arrangement of fingers within the open reading frame shown in Figure 1 distinguish Hb-like family members from all other [C.
Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains
Their DNA repair antibody catalog includes antibodies for the study of double-stranded DNA break repair, chromatin interactions, zinc finger domains
, DNA replication, and more.
The number of physiological functions which is attributed to zinc is growing, since it has been estimated that zinc finger domains
are coded by up to 3% of the human genome.
LIM domains, named after their initial discovery in the proteins Lin11, Isl-1, and Mec-3, are cysteine-rich protein motifs composed of two contiguous zinc finger domains
separated by a two-amino acid residue hydrophobic linker.
The positive regulatory domain I-binding factor 1 and retinoblastoma protein-interacting zinc finger gene homology domain containing (PRDI-BF1 and RIZ homology domain containing, PRDM) family is a novel transcription regulator containing a N-terminal positive regulatory domain, followed by six deoxyribonucleic acid (DNA)-binding C2H2 zinc finger domains
involved in human tumorigenesis.