For example, streptozotocin--(STZ-) induced diabetic rats exhibit a blunted circadian rhythm of locomotor activity with a normal phase entrainment , whereas Zucker obese rats, an animal model of type 2 DM (T2DM), exhibit a phase advance and blunted amplitude of locomotor activity .
For example, Zucker obese rats, an animal model for T2DM with mutations in the leptin receptor, exhibit a phase advance and a decreased amplitude of activity and body temperature .
Training RT-Lean Attempts RT-Obese Weeks Total Overload Total Overload Lifted (g) Lifted (g) 1st 14.360 [+ or -] 1.243 6 12.944 [+ or -] 1.583 2nd 15.570 [+ or -] 1.456 7 11.965 [+ or -] 1.081 3rd 17.432 [+ or -] 2.216 8 14.400 [+ or -] 670 4th 18.776 [+ or -] 2.203 6 14.730 [+ or -] 640 Training Attempts P Value Weeks 1st 6 0.208 2nd 6 0.007 3rd 8 0.039 4th 4 0.012 RT = Lean, Resistance Training Zucker Lean Rats; RT-O = Resistance Training Zucker Obese Rats
; Total Overload Lifted = Sets*Repetitions*Weight; All values are presented as means [+ or -] SD.
Data presented here shows for the first time that Rapamycin modulates several intracardiac proteins differentially in healthy Zucker lean rats and diabetic Zucker obese rats
. Our expectation was that since Rapamycin is an immunosuppressant, it would suppress inflammatory cytokines in the heart of both lean and obese rats to improve their cardiac function.
Atkinson, "Effects of ileal transposition on food intake, dietary preference, and weight gain in Zucker obese rats
," The American Journal of Physiology--Regulatory Integrative and Comparative Physiology, vol.
(36.) Saito M, Ueno M, Ogino S, et at.: High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis.
(27.) Greenwood MR, Cleary MP, Gruen D, et al.: Effect of(-) hydroxycitrate on de-velopment of obesity in Zucker obese rat. Am J Physiology 240:E72-E78, 1981.
The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats
. Kidney Int.
In two separate studies, male Sprague-Dawley or female Zucker obese rats, injected with azoxymethane (15 or 10 mg/kg body wt.
This investigation was carried out in two animal models of colon cancer, one that is sporadic (Sprague-Dawley rats) and one that is associated with obesity (Zucker obese rats); both are induced with AOM (Corpet and Tache, 2002; Raju and Bird, 2003).
for the first time revealed that long time treatment with rapamycin modulates several intracardiac proteins differentially in healthy Zucker lean rats and diabetic Zucker obese rats
. They showed that rapamycin treatment causes an increase in cardiac fibrosis in healthy Zucker lean rats, whereas rapamycin suppresses cardiac fibrosis in Zucker obese rats
by differentially regulating the phosphorylation of AKT and antifibrotic cytokines in healthy and obese rats.
Kim et al., "Augmented contractile function and abnormal [Ca.sup.2+] handling in the aorta of Zucker obese rats
with insulin resistance," Diabetes, vol.