In: Immunogenetic studies of
autoimmune hepatitis and primary sclerosing cholangitis.
Lawrence et al., "Concurrent extra-hepatic autoimmunity in
autoimmune hepatitis: implications for diagnosis, clinical course and long-term outcomes," Liver International, 2016.
Patients with seronegative
autoimmune hepatitis (SAIH) have demographic, biochemical, and histologic features of classical AIH but negative autoimmune serology.
Vergani, "Adaptive immunity in
autoimmune hepatitis," Digestive Diseases, vol.
Moreover, sometimes there are overlapping profiles with other autoimmune diseases, such as
autoimmune hepatitis, acute hemolytic anemia, and primary biliary cirrhosis which could result in higher levels of hepatic enzymes.
Prevalence and epidemiology of
autoimmune hepatitis. Clin Liver Dis.
Clinical features of
autoimmune hepatitis patients with cirrhosis
Among the patients who underwent liver biopsy, 18 patients (60%) had cryptogenic cirrhosis, 6 patients (20%) had NASH and 3 patients (10%) had
autoimmune hepatitis. Commonly seen complications were ascites (82%), variceal bleeding (38%), hepatic encephalopathy (16.5%), SBP (3%), HRS (2.5%) and HCC (1.5%).
Regarding chronic liver etiology, 75 individuals were classified as chronic HCV patients (56.4%), 25 as HBV patients (18.8%), 15 with alcoholic liver cirrhosis (11.3%), 8 with
autoimmune hepatitis (6%), 4 with NAFLD (3%), 1 with cryptogenic hepatitis (0.8%), and 5 had other causes of cirrhosis (3.8%).
that normal " Erin was just 16 when she was diagnosed with
autoimmune hepatitis. Th 16-year-rare condition rarely has signs or symptoms.
The management consisted primarily in the exclusion of other causes of liver injury/cholestasis such as viral etiology (antibodies IgM antiHAV or a possible reactivation of HBV) other toxic,
autoimmune hepatitis, Wilson disease, hemochromatosis, alpha1-antitrypsin deficiency, shock liver, acute cholecystitis, cholangitis, Budd-Chiari syndrome, alcoholic liver disease, malignancy, coagulation disorders [3].