It is not then a surprise to find that JAs can inhibit the
lipoxygenase pathway in animals, MJ being itself a secondary cyclopentanone product derived from of a-linolenic acid.
Castonguay, "Inhibitors of
lipoxygenase: a new class of cancer chemopreventive agents," Carcinogenesis, vol.
Abbreviations DMEM: Dulbecco's modified Eagle's medium FBS: Fetal bovine serum FLAP: Five
lipoxygenase activating protein IBMX: 3-Isobutyl-1-methylxanthine 5-LOX: 5-Lipoxygenase SGADs: Second-generation antipsychotic drugs SREBP-1: Sterol regulatory element binding protein-1.
Van Leyen, "12/15
Lipoxygenase targets neuronal mitochondria under oxidative stress," Journal of Neurochemistry, vol.
These data indicate that the inhibition of COX in OA cartilage results in the increased utilization of arachidonic acid substrate by the
lipoxygenase pathway.
The released AA could be further metabolized by three different types of oxygenases: cytochrome P450 (CYP), cyclooxygenase (COX), and
lipoxygenase (LOX) (Roman et al., 2002).
The mechanism of
lipoxygenase inhibitor-induced apoptosis in human breast cancer cells.
Kanto-101 is a Japanese line that lacks seed
lipoxygenases 2 and 3, and was used as a donor of the [lx.sub.2] anl [lx.sub.3] null genes (Kitamura et al., 1985).
Lipoxygenases are dioxygenases found ubiquitously in higher plants and animals.
EDTA chelates the calcium required for the phospholipase [A.sub.2] activation, and therefore less arachidonic acid is available for both the cyclooxygenase and
lipoxygenase pathways [221.
Researchers have pinpointed the enzyme
lipoxygenase as the cause of the beany flavor and are now breeding low
lipoxygenase soybeans.