Tivozanib is approved in the European Union, as well as Norway and Iceland, for the first-line treatment of adult patients with RCC and for adult patients who are
vascular endothelial growth factor receptor and mTOR pathway inhibitor-naive following disease progression after one prior treatment with cytokine therapy for RCC.
Assignment of
vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively.
The growth factor which stimulates angiogenesis and vasculogenesis is called
vascular endothelial growth factor (VEGF).
Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair.
Nadler, "Effects of high glucose on
vascular endothelial growth factor expression in vascular smooth muscle cells," American Journal of Physiology--Heart and Circulatory Physiology, vol.
(1994) Glomerular endothelial cells in culture express and secrete
vascular endothelial growth factor. Am J Physiol 266: F81-F88.
Wilson et al., "Localization and quantification of cyclic changes in the expression of endocrine gland
vascular endothelial growth factor in the human corpus luteum," The Journal of Clinical Endocrinology and Metabolism, vol.
Meng et al., "Domain I-IV of beta2-glycoprotein I inhibits advanced glycation end product-induced angiogenesis by down-regulating
vascular endothelial growth factor 2 signaling," Molecular Medicine Reports, vol.
Vascular endothelial growth factor expression and microvessel density – Two useful tools for the assessment of prognosis and survival in gastric cancer patients.
Vascular endothelial growth factor: molecular and biological aspects.