aGVHD

AcronymDefinition
aGVHDAcute Graft Versus Host Disease
References in periodicals archive ?
Infusion of IL-22Ab Markedly Suppressed Donor Cell Engraftment and Prevented the Disease-Associated Depletion of Host Cells in aGVHD Mice.
Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing [Foxp3.sup.+] T Cell through Modulation of [CD11b.sup.+] Cell Function
HLA loci have also been reported to have impacts on acute graft-versus-host disease (aGVHD),[sup][13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23],[24] which is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Impact of Human Leukocyte Antigen Loci and Haplotypes on Intestinal Acute Graft-versus-host Disease after Human Leukocyte Antigen-matched Sibling Peripheral Blood Stem Cell Transplantation
Australia-based Mesoblast's intravenous product candidate, MSC-100-IV, has been successful in a pre-specified interim futility analysis in the phase three trial of the product that was used as front-line therapy in children with steroid-resistant acute graft versus host disease (aGVHD), it was reported yesterday.
Mesoblast's MSC-100-IV successful in pre-specified interim futility analysis in phase three aGVHD trial
The endpoints of this study were engraftment, aGVHD and cGVHD, infectious complications, non-relapse mortality (NRM), relapse rate, disease-free survival (DFS), and overall survival (OS).
Salvaged single-unit cord blood transplantation for 26 patients with hematologic malignancies not in remission
IL-17A and IL-17F Levels in Blood and Saliva and the Incidence of aGVHD. No association was found between IL17A or IL-17F levels in the blood or saliva samples and the occurrence of systemic cGVHD (data not shown).
IL-17 genetic and immunophenotypic evaluation in chronic graft-versus-host disease
Liver biopsy is not particularly helpful in establishing a drug-induced hepatotoxicity, but is important in excluding other causes of liver disease such as SOS, aGVHD and sepsis.
Hepatic complications of allogeneic hematopoietic cell transplantation/Allojeneik hematopoetik hucre naklinin hepatik komplikasyonlari
The company plans to broaden its use in adult patients with high-risk steroid-refractory aGVHD.
Positive interim analysis in phase 3 trial for acute GvHD: Mesoblast prepares for commercial launch
Acute and cGVHD (aGVHD) were graded by the Seattle criteria.
Granulocyte Colony-stimulating Factor-primed Bone Marrow: An Excellent Stem-cell Source for Transplantation in Acute Myelocytic Leukemia and Chronic Myelocytic Leukemia
Several studies on myeloablative conditioning allogeneic transplantation have shown that low whole blood concentrations of CsA during the periengraftment period can strongly affect the incidence of grade 2-4 acute GVHD (aGVHD) [5, 6].
Impact of cyclosporine levels on the development of acute graft versus host disease after reduced intensity conditioning allogeneic stem cell transplantation
Mesoblast initiated a rolling Biologics License Application (BLA) with the United States Food and Drug Administration (FDA) for remestemcel-L in the treatment of pediatric aGVHD; in preparation for product launch, focus is on inventory and commercial team ramp up.
Mesoblast Quarterly Cash Flow Report
Mesoblast plans to file for United States FDA regulatory approval of remestemcel-L shortly for the treatment of aGVHD.
Mesoblast licensee files for marketing approval of TEMCELL
Proceeds will be primarily used towards funding the commercialization of MSC-100-IV (remestemcel-L) after this product candidate successfully met its Phase 3 trial's primary endpoint of Day 28 overall response in children with steroid refractory acute Graft versus Host Disease (aGVHD).
Finance Company Loans Mesoblast $75 Million
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