References in periodicals archive ?
Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia. PLoS One.
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368(22): 2059-74.
"Conventional chemotherapy is not effective for most patients with acute myeloid leukemia. The new results with venetoclax look very promising," Jordan said.
Moreover complex karyotype was most frequently associated with myelodysplastic syndromes and acute myeloid leukemia. We also assessed complex karyotype in benign diseases, though not significant; one patient with diagnosis of aplastic anemia had the complex cytogenetics.
Out of total 35 cases of leukemia, 21(14.2%) were Acute Myeloid Leukemia and 6(4.1%) were Acute Lymphocytic Leukemia.6
Conventional cytogenetics is still the most important independent prognostic factor in acute myeloid leukemia, but more and more genetic mutations are with proven prognostic significance.
Acute myeloid leukemia (AML) is a heterogeneous disease with diverse genomic aberrations in the subtypes.[sup][1] While a great number of cytogenetic abnormalities has been identified in AML,[sup][2] approximately 45% of de novo adult AML patients and 20% of pediatric AML patients are diagnosed with cytogenetically normal AML (CN-AML).[sup][1],[2] It is important to study the predictive molecular markers so that patients can get better treatment.
Ganser, "How i treat refractory and early relapsed acute myeloid leukemia," Blood, vol.
Chen, "Spontaneous remission in patients with acute myeloid leukemia with t(8;21) or cutaneous myeloid sarcoma: two case reports and a review of the literature," Internal Medicine, vol.
Marcucci, "Molecular prognostic factors in cytogenetically normal acute myeloid leukemia," Expert Review of Hematology, vol.
The report provides comprehensive information on the therapeutics under development for Refractory Acute Myeloid Leukemia, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
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