Acute Promyelocytic leukemia
(APL): Patients with all of the following features were diagnosed as having APL:
Xiong et al., "Molecular cytogenetic characterization and clinical relevance of additional, complex and/or variant chromosome abnormalities in acute promyelocytic leukemia
," Leukemia, vol.
Kalmanti, "A comprehensive review of acute promyelocytic leukemia
in children," Acta Haematologica, vol.
For further evaluation, bone marrow aspiration was done which suggestive of acute promyelocytic leukemia
(APL) (FAB M3).
(11) Also noteworthy is that 97.7% of respondents reported performing FISH or molecular genetic testing for PML-RARA on patients with suspected acute promyelocytic leukemia
, but this testing should be performed in all cases of suspected acute promyelocytic leukemia
Morphologic features, flow cytometric findings, and molecular genetic studies were diagnostic of an acute promyelocytic leukemia
(APL) with t(15; 17)(q22; q21); PML/RARA and concomitant B cell chronic lymphocytic leukemia (CLL).
Lo-Coco, "Current management of newly diagnosed acute promyelocytic leukemia
," Annals of Oncology, vol.
Chen, "How to manage acute promyelocytic leukemia
," Leukemia, vol.
* 20 of the 40 druggable genes are already approved by the FDA to treat a range of medical disorders, including glaucoma, epilepsy, hypertension, angina, irritable bowel syndrome, incontinence, smoking cessation, nausea, hypertension, prostate cancer, type 2 diabetes mellitus, pulmonary fibrosis, and acute promyelocytic leukemia
; in addition, some genes act as a diuretic or an nonsteroidal anti-inflammatory drug
The treatment of acute promyelocytic leukemia
(APL) has improved remarkably during the last two decades mainly due to disease-specific drugs, such as all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) [1, 2].
(17) AZA, SSZ 13 Our study SSZ TNF-[alpha]: Anti-tumor necrosis factor-alpha; F: Female; M: Male; AS: Ankylosing spondylitis; AML: Acute myeloid leukemia; SSZ: Sulfasalazine; AZA: Azathioprine; CD: Crohn's disease; Ph+: Philadelphia chromo-some-positive; ALL: Acute lymphoid leukemia; MTX: Methotrexate; PsA: Psoriatic arthritis; JRA: Juvenile rheumatoid arthritis; LFN: Leflunomide; MDS: Myelodysplastic syndrome; HQ: Hydroxychloroquine; CLV: Cutaneous lymphocytic vasculitis; MMF: Mycophenolate mofetil; APL: Acute promyelocytic leukemia
Acute promyelocytic leukemia
(APL) and myelodysplastic syndromes (MDS)/therapy-related AML are two subtypes of AML that are especially unique in terms of disease etiology and prognosis, both of which will be discussed in detail in this report.