Rising focus on identification of new drug targets for atherosclerosis
The researchers emphasise, in conclusion, "Oral infections were an independent risk factor for subclinical atherosclerosis
, and their association with cardiovascular risk factors persevered through the entire follow-up.
The investigators found also that, in contrast with CIMT, cardiac computed tomography (CT) measures of atherosclerosis
did not differ significantly between the estradiol and placebo groups, regardless of age.
'What we found was that patients with unexplained atherosclerosis
had significantly higher blood levels of these toxic metabolites that are produced by the intestinal bacteria,' said David Spence, Professor at Western University, London, Canada.
Sample size was based on the study by Sinha et al24, the plaque of atherosclerosis
in GCSF and control groups (S1=0.005,S2=0.014,u1=0.058, u2=0.039), n=6, for each group, as following:
Carotid intima-media thickness is defined as the distance between the luminal–endothelial interface and the junction between the media and the adventitia on a longitudinal ultrasound image of each artery.[sup], As a surrogate marker of atherosclerosis
, intima-media thickness levels greater than 0.9 mm were associated with atherosclerosis
In the present study, heart specimens of 600 consecutive post-mortem cases, received in die pathology section of the JLN Medical College, Ajmer, were examined grossly and microscopically for the presence and extent of atherosclerosis
and evidence of myocardial infarction (MI).
Smooth Muscle Cells Contributing to Atherosclerosis
. The relationship between SMCs and atherosclerosis
has considerably drawn attention since Ross et al.
The concept of atherosclerosis
as an inflammatory disease is based on the evidence that inflammatory cells are abundant in atherosclerotic lesions, which are the major source of cytokine that was involved in all stages of atherosclerosis
and have a profound impact on the pathogenesis of this disease .
Purpose: Herein, the effect of artesunate, a derivant from artemisinin from the traditional Chinese herb sweet wormwood, could attenuate the progression of atherosclerosis
lesion formation alone or combined with rosuvastatin in Western-type diet (WD) fed [ApoE.sup.-/-] mice, and explored its possible mechanisms.
The study of 8,020 adult Korean men without carotid atherosclerosis
at baseline showed that men with persistent NAFLD had a 13% greater risk of subclinical carotid atherosclerosis
, compared with those without NAFLD, after adjustment for age, smoking, alcohol, body mass index, and weight change (95% confidence interval, 1.131.35; P less than .001).
The report provides comprehensive information on the therapeutics under development for Atherosclerosis
, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.