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AFXAtypical Fibroxanthoma (a malignant or benign neoplasm of the connective tissue)
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Caption: Atypical fibroxanthoma in the 77-year-old patient is described in the column.
Atypical fibroxanthoma is a rare, benign, dermally based tumor of uncertain lineage.
Atypical fibroxanthoma (AFX) is a rare, superficial fibrohistiocytic skin tumour composed predominantly of fusiform, epithelioid, spindle, and pleomorphic cells [1].
These include metastatic carcinoma, malignant melanoma, anaplastic large cell lymphoma, pleomorphic dermal sarcoma, atypical fibroxanthoma, and myeloid sarcoma [3].
Differential diagnosis of GCT-ST includes soft tissue mesenchymal tumour which are rich in giant cell, villonodular sinuvitis, cellular dermatofibroma, atypical fibroxanthoma, plexiform fibrohistiocytic tumour, malignant fibrous histiocytoma, leiomyosarcoma, extraskeletal osteosarcoma and epithelioid sarcoma.6
The other tumors rarely seen were dermatofibroma, atypical fibroxanthoma and Kaposi's sarcoma and actinic Keratosis.
While cytological features may not enable distinction from a spindle cell SCC and atypical fibroxanthoma (AFX), the presence of a junctional component helps delineate spindle cell melanoma (Figure 23).
Atypical fibroxanthoma (AFX) is a cell neoplasm occurring mainly (or only, according to some criteria) on sunexposed skin.
This tumor is believed to be secondary to UV exposure, but unlike lentigo maligna, atypical fibroxanthoma (AFX) seems to be confined to an older population.
Skin cancer can include squamous cell carcinoma, basal cell carcinoma, melanoma, sarcoma, Merkel cell carcinoma, angiosarcoma, verrucous carcinoma, atypical fibroxanthoma, and leiomyosarcoma.
They include atypical fibroxanthoma, spindle-cell carcinoma, amelanotic malignant mucosal melanoma, osteosarcoma, fibrosarcoma, pleomorphic rhabdomyosarcoma, pleomorphic liposarcoma, dedifferentiated sarcomas, and glioblastoma multiforme.
Undifferentiated Pleomorphic Sarcoma (Previously Known as Malignant Fibrous Histiocytoma), Atypical Fibroxanthoma, and Myxofibrosarcoma.--These tumors all have striking nuclear pleomorphism similar to superficial [CD34.sup.+] fibroblastic tumor.
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