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References in periodicals archive ?
A bradykinin antagonist inhibits carrageenan edema in rats.
Scientists have associated both of these compounds with lung cancer tissue: bradykinin is thought to directly stimulate the growth of lung cancer, while lung cancer tissue expresses substance P, possibly encouraging tumor proliferation.
Bradykinin increases the production of nitric oxide (NO); a potent vasodilator that is also produced by shear force on endothelial cells (11).
Hydrolysis of plasminogen to plasmin by tPA activates the kinin pathway by converting Factor XII to Factor XIIa which will cause an increase in production of bradykinin. Bradykinin is a powerful vasodilator peptide that activates vascular bradykinin B2 receptors which are responsible for causing angioedema.
The purified synthetic replicates of Caeridins were subjected to antimicrobial activity tests, with melittin and bradykinin as positive and negative controls, respectively.
Peronnet, "Increase in blood bradykinin concentration after eccentric weight-training exercise in men," Journal of Applied Physiology, vol.
Mild cases may respond to antihistamines, while more severe cases may require corticosteroids, epinephrine, and even bradykinin antagonists like Icatibant.
During an HAE attack, the system is triggered (by minor trauma, drugs, stress, or physical activities) leading to increased levels of bradykinin, which increases vascular permeability and causes angioedema, presenting as skin swellings, abdominal pain, tongue swellings, and upper respiratory airways obstruction (i.e., laryngeal edema) [2].
As an important element of the kallikrein/kinin system (KKS), tissue kallikrein can cleave low-molecule kininogen into kinins (e.g., bradykinin and kallidin).
In the context of bradykinin mediated angioedema, female sex hormones act on the kallikrein-kinin system by increasing synthesis of bradykinin.
identified that the bradykinin receptor B2 (BDKRB2) is of particular interest in disease progression of DPN.