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cIAP1cellular inhibitor of apoptosis 1
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Zhang et al., "LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC," Journal of Experimental & Clinical Cancer Research, vol.
cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production.
Bogaert et al., "cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production," Cell Death and Differentiation, vol.
Las proteinas inhibidoras de la apoptosis IAPs estan involucradas en el bloqueo de la cascada de las caspasas, habiendose identificado ocho en humanos, entre ellas XIAP, cIAP1, cIAP2, NAIP y survivina (45, 46).
The data, published at the 2011 AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics in San Francisco, showed that TL32711 caused potent and sustained suppression of inhibitor of apoptosis protein cIAP1 in patient peripheral blood mononuclear cells (PBMCs) and tumour biopsies over seven days at tolerable dose levels with evidence of apoptosis pathway activation and promising early signs of anti-tumour activity in patients.
(18) At least 3 classes of IAPs composed of a total of 8 proteins have been identified in humans including the best known cIAP1, cIAP2, and XIAP.
Se ha descubierto que la liberacion de citocromo c activa la proteina Apaf-1 (en ingles: Apoptotic protease activating factor-1) y la procaspasa-9, ademas de ATP, estableciendo un complejo proteico denominado "apoptosoma", el cual activa la caspasa-3, iniciando la via efectora de apoptosis (Chinnaiyan, 1999; Hill et al., 2004; Huerta et al., 2007), mientras que las proteinas Smac/Diablo y HtrA2/Om promueven apoptosis por inhibicion de IAP (inhibidores de proteinas apoptoticas) como cIAP1, cIAP2 y XIAP (Elmore, 2007; Huerta et al., 2007); 2) factores inductores de apoptosis (AIF), endonucelasa G y la DNasa activada por caspasas (CAD).
Como ya mencionamos, Smac/DIABLO, puede liberar a las procaspasas de la influencia inhibidora de las IAP, como XIAP (proteina inhibidora de apoptosis ligada al X), CIAP1 (proteina inhibidora de apoptosis celular 1), CIAP2 (proteina inhibidora de apoptosis celular 2) y NIAP (proteina inhibidora de apoptosis neuronal), para que sean activadas por auto catalisis.
To the best of our knowledge, ILf2 also could inhibit the apoptosis of liver cancer cells through regulating the expression of B-cell lymphoma 2 (Bcl-2), Bcl-2 related ovarian killer (Bok), Bcl-2-associated X protein (BAX), and cellular inhibitor of apoptosis 1 (cIAP1) to facilitate the genesis and progression of liver cancer [20].
This family of proteins consists of 8 members: NAIP, XIAP, cIAP1, cIAP2, ILP2, livin, survivin, and BRUCE [65, 66].