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cIAP1cellular inhibitor of apoptosis 1
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The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases.
The data, published at the 2011 AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics in San Francisco, showed that TL32711 caused potent and sustained suppression of inhibitor of apoptosis protein cIAP1 in patient peripheral blood mononuclear cells (PBMCs) and tumour biopsies over seven days at tolerable dose levels with evidence of apoptosis pathway activation and promising early signs of anti-tumour activity in patients.
18) At least 3 classes of IAPs composed of a total of 8 proteins have been identified in humans including the best known cIAP1, cIAP2, and XIAP.