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cIAP2cellular inhibitor of apoptosis 2
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Zhang et al., "LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC," Journal of Experimental & Clinical Cancer Research, vol.
Moreover, HuR has been shown to be associated with molecules controlling cell apoptosis (i.e., cIAP2 in OSCCs) [64] and cell proliferation or cycle regulation (i.e., Ki-67 index in thyroid tissue, cyclins A, B1, and D1, CDK1 in OSCCs, survivin in human eosophageal epithelial cells) [21, 98, 101].
By investigating the role played by cIAP2 in mice with the H1N1 influenza A virus, what Saleh and her team discovered was that the enzyme is necessary to control the nature of cell death during influenza infection.
The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases.
Similar to Smac/DIABLO, HtrA2/Omi binds to and neutralizes IAPs (XIAP, cIAP1, and cIAP2) via its N-terminal IAP-binding motif, therefore releasing the inhibition of IAP to caspase-3, -7, and -9.
AT-406 is a multi-IAP inhibitor (including XIAP, cIAP1, cIAP2, ML-IAP).
Se ha descubierto que la liberacion de citocromo c activa la proteina Apaf-1 (en ingles: Apoptotic protease activating factor-1) y la procaspasa-9, ademas de ATP, estableciendo un complejo proteico denominado "apoptosoma", el cual activa la caspasa-3, iniciando la via efectora de apoptosis (Chinnaiyan, 1999; Hill et al., 2004; Huerta et al., 2007), mientras que las proteinas Smac/Diablo y HtrA2/Om promueven apoptosis por inhibicion de IAP (inhibidores de proteinas apoptoticas) como cIAP1, cIAP2 y XIAP (Elmore, 2007; Huerta et al., 2007); 2) factores inductores de apoptosis (AIF), endonucelasa G y la DNasa activada por caspasas (CAD).
Como ya mencionamos, Smac/DIABLO, puede liberar a las procaspasas de la influencia inhibidora de las IAP, como XIAP (proteina inhibidora de apoptosis ligada al X), CIAP1 (proteina inhibidora de apoptosis celular 1), CIAP2 (proteina inhibidora de apoptosis celular 2) y NIAP (proteina inhibidora de apoptosis neuronal), para que sean activadas por auto catalisis.
NF-[kappa]B antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and cIAP2 to suppress caspase-8 activation.
These intracellular targets include TNF receptor-associated factor 2 (TRAF2, an E3 ubiquitin ligase that is a key component of the NF[kappa]B pathway [50]; apoptosis inhibitor cIAP2, an E3 ubiquitin ligase that is a key component of the IRF-1 (interferon-regulatory factor 1-) mediated immune and sterile inflammation) [51].
Washington, Jan 16 ( ANI ): Researchers have found a new enzyme, known as cIAP2, which helps the lungs fight against infection by giving them the ability to decrease flu-inflicted tissue injury.