70) Galliard's enzyme mentioned above, (58) the cPLA2
reported by Senda et al.
Calcium resides at the catalytic center of sPLA2 and is directly involved in substrate-enzyme interaction (15), whereas it is not required for cPLA2
catalytic activity but rather involved in the translocation of cPLA2
from cytosol to the membrane where the substrates are located (16).
PLA2R1 tiene una cascada de senalizacion intracelular donde se han dilucidado componentes como la p38MAPK (del ingles mitogen-activated protein kinase kinase), e incluso, lejos de ser curioso y no coincidente, las cPLA2
This asset is supported by several other potential products in our pipeline, including a topical cPLA2
inhibitor which I believe is the most advanced in development worldwide.
NOX, NADPH oxidases; TNF-[alpha], tumor necrosis factor-a; EGF, epidermal growth factor; IL-1[beta], Interleukin-1[beta]; SOD, superoxide dismutase; GPx, glutathione peroxidase; GST-pi, glutathione S-transferase pi; MT3, metallothionein-3; FHC, ferritin heavy chain; DDH1, dihydrodiol dehydrogenase; TNFR, tumor necrosis factor receptor; TRADD, TNFRSF1A-associated via death domain; MyD88, myeloid differentiation factor 88; TLR, Toll-like receptor; cPLA2
, cytosolic phospholipases A2.
19) Se ha involucrado a la cPLA2
en los recambios de fosfolipidos en las caras internas de la membrana durante su remodelacion.
BL-3030 is aimed at inhibiting the formation of cPLA2
- an enzyme that plays a major role in a number of inflammatory diseases including rheumatoid arthritis (RA), asthma, and adult respiratory distress syndrome (ARDS).
AP-1 = activator protein-1, COX-2 = cyclooxygenase-2, cPLA2
= cytosolic phospholipase A2, ERKs = extracellular signal regulated kinases, ICAM-1 = intercellular adhesion molecule-1, IL-1 = interleukin-1, IL-8 = interleukin-8, iNOS = inducible nitric oxide synthase, JNKs = c-jun N-terminal kinases, LPO = lipoxygenase, MAPK p38 = mitogen activated protein kinase p38, PI3K = phosphatidylinositol-4,5-bisphosphate 3-kinase, MMP-9 = matrix metalloproteinase-9, MPO = myeloperoxidase, NF-[kappa]B = nuclear factor kappa B, [PGE.