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As for the catalytic serine, aspartic acid and arginine, cPLA2, P.
 reported that the OS induced in the retina in the presence of iron seems to be related to AMD by means of cytosolic phospholipase A2 (cPLA2) and calcium-independent isoform (iPLA2) actions.
Ye, "Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-y-independent manner," Basic Research in Cardiology, vol.
Interestingly, a recent study showed that the BanI polymorphism in PLA2G4A (cytosolic PLA2; cPLA2) affects the mean age of schizophrenia onset only in male patients. Evidence suggests that sex differences among patients with schizophrenia have included age of onset, symptom severity, treatment response, course of illness, and outcome, favouring females, which may be associated with the neuroprotective action of female sex hormones in the brain.
OMT protects neurons through down-regulation of 12/15-LOX, phospho-p38 MAPK, and cPLA2 in acute-permanent, middle-cerebral artery occlusion (MCAO) (Cui et al.
Prostaglandins are synthesized by enzyme cascades initiated by the release of arachidonic acid from membrane phospholipids due to the action of cytosolic phospholipase A2 (cPLA2) or secretory PLA2 (sPLA2).
Centella asiatica water extract inhibits iPLA2 and cPLA2 activities in rat cerebellum.
Although 22 different PLA2 enzymes classified in 5 families (sPLA2, cPLA2, iPLA2, PAF-AH, and lysosomal PLA2) have been identified (1), no specific tool allowing the specific characterization of each of these isoenzyme is available to date.
NT may enhance 5-HETE formation by Ca2+-mediated and ERKmediated activation of DAG lipase and cPLA2. NT also upregulates cPLA2 and 5-LOX protein expression.
Involvement of endothelial cPLA2. J Leukoc Biol 2000, 68: 881-889.
Las variedades citosolicas calcio-dependientes (iPLA2 o cPLA2) corresponden en la clasificacion general propuesta por la IUBMB al grupo IVA, y se han encontrado cuatro grandes tipos de miembros o isoenzimas en mamiferos: cPLA2alfa, cPLA2beta, cPLA2gamma y cPLA2delta.
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- cPLA(2)-interacting protein
- cPLA2 interacting protein