Drug-induced systemic lupus erythematosus after 7 years of treatment with carbamazepine
. Acta Biomed 2006; 77: 17-9.
(CBZ) is one of the anticonvulsant drugs that is widely used to treat partial tonic clonic seizure in children and adults.
and valproic acid were discontinued and intensive methylprednisolone (at a dose of 20 mg/kg for three days) was initiated and a maintenance treatment with a dose of 2 mg/kg/day was applied.
Caffeine (98%, CAS 5808-2) and atrazine (99%, CAS 1912-24-9) were purchased from Fluka Analytical (USA), whereas carbamazepine
(99%, CAS 298-46-4) was obtained from Sigma-Aldrich (USA).
found a strong association between the presence of the HLA-B * 15:02 allele and SJS/TEN induced by carbamazepine
Epilepsy has no relation with age, race, socio-geographic or national boundaries.3 Different drugs for the treatment of epilepsy are available but the most common treatment for epilepsy is monotherapy with antiepileptic drugs (AEDs) and about 50% patients are treated successfully with monotherapy.4 Carbamazepine
(CBZ) is used as a first line drug to control different forms of epilepsy.
-the commonest cause of toxic epidermal necrolysis and steven Johnson syndrome: A study of 7 years.
 In fact the HLAB*1502 allele has been linked with carbamazepine
induced SJS in Thai population.
The trial compared once-daily eslicarbazepine acetate as monotherapy to twice-daily, controlled-release carbamazepine
as a treatment for newly diagnosed adults with partial-onset seizures.
About 35.07% of the patients received carbamazepine
as monotherapy followed by phenytoin in 11.94% and phenobarbitone in 8.95% patients.
Cyclical anticonvulsants including phenytoin, phenobarbital, and carbamazepine
are the most common culprits, but AHS has also been reported with lamotrigine and valproic acid (1).
(CBZ) remains the first-line therapy for trigeminal neuralgia (TGN) [1, 2].