But the specific molecular pathways regulate cell cycle of normal zygotes and zygotes with oxidative-stressed damage are unclear, and whether DNA damage in zygotes activates cascade of ATM [right arrow] Chkl
[right arrow] Cdc25B/Cdc25C during G2/M to repair the damage depends on our further study.
Here we found that the phosphorylation of ATM, ATR, Chkl
, and Chk2 was increased suggesting that PSO activated both ATM-Chk2 and ATR-Chkl
The key regulators in response to DNA damage are ATM and ATR kinases, which activated Chkl
and Chk2 .
In chromosome 9, one of these "hot spots" contained two genes that are known to be involved in cancer: the tumor suppressor gene ATM and the gene for Chkl
, which functions in the repair of damaged DNA (Hunter et al.
Exposure to chelidonine slightly increased the amount of Chkl
phosphorylated at Ser345 in both examined cell lines.