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CHKLCity Hall Kuala Lumpur (Malaysia)
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Both Amaryllidaceae alkaloids accumulate cells preferentially at G1 and G2 stages of the cell cycle with increased pi 6 expression and Chkl Ser345 phosphorylation.
In chromosome 9, one of these "hot spots" contained two genes that are known to be involved in cancer: the tumor suppressor gene ATM and the gene for Chkl, which functions in the repair of damaged DNA (Hunter et al.