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References in periodicals archive ?
maritimum extracts affected the expression of Bcl-2, cyclin B1 and Ki67 in MDA-MB-231 cells in a time- and concentration-dependent manner.
63) Weak cyclin D1 staining can be observed in most HCLs (Figure 7, C), but there is no rearrangement of the cyclin D1 gene at 11q13 locus.
The membranes were probed with mouse anti-phospho-ERK5 (p-ERK5), ERK5, p-MAP3K7, MAP3K7 and cyclin D1 polyclonal antibodies (1:500, Santa Cruz) and mouse anti-GAPDH monoclonal antibody (1:2000, Sigma) overnight at 4[degrees]C, respectively.
In this study, we investigated expression of RET, p27 and cyclin D1 in papillary thyroid microcarcinoma with or without regional lymph node metastases, to reveal differences in biological profile due to clinical behavior.
growth hormones that directly target Cyclin E/CDK2 complex which on activation hyper- phosphorylate the pRb at G1.
In colon adenocarcinoma cells, CA reduced leptin signaling through the inhibition of the phosphorylation of AKT, ERK and 1R, which caused a reduced expression of both BCL-XL and Cyclin DI resulting in cell cycle arrest (Kim et al.
The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention.
Cyclin D1 amplification and consequently overexpression of its protein "cyclin D1" envisage poor outcome as evidenced by a study by Seiler et al.
Furthermore, cyclin D1 levels were significantly reduced in Ad-Bach1 HMVECs but increased significantly when the cells were cultured with NAC (Figures 6(a) and 6(b)).
1 These compounds down regulate the expressions of cdK2, cdK4, cyclin D1, cyclin D3, inhibit Tumour Necrosis Factor (TNF) induce COX-2 expression and activate the transcription factor NFKB.
Washington, Nov 30 ( ANI ): A new study has found that cyclin D1, a protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA (miRNA).