dMCAO

AcronymDefinition
dMCAODistal Middle Cerebral Artery Occlusion
References in periodicals archive ?
However, the infiltrated neutrophils and T cells did not produce BDNF, and only few of them (1-5%) were positive for TNF-[alpha] or IL-1[beta] two days after dMCAO. Among the [Ly6C.sup.+] infiltrated cells, it is probably monocytes/macrophages that are the major contributors for production of BDNF, IL-1[beta], and TNF-[alpha].
In this study, we found that dMCAO leads to infiltration of [Ly6C.sup.+] cells into the brain after stroke.
Now we have demonstrated that monocytes/macrophages are probably another important participant that mediates the neurotrophic effects after dMCAO. At 48 h after ischemia onset, nearly 32.40% of [Ly6C.sup.+] cells were BDNF-positive.
In our study, intravenous transplantation of mesenchymal stem cells reduces the number of infiltrated macrophages but enhances the proportions positive for BDNF, TNF-[alpha], and IL-1[beta] in the infarct cortices of dMCAO rats.
The number of [Ly6C.sup.+] cells gradually increases at the IBZ of infarct dMCAO in rats.
(d) Double-stained [Ly6C.sup.+]/[BDNF.sup.+] cells scattered in the infarct area after dMCAO. (h) [Ly6C.sup.+]/[BDNF.sup.+] cells 2 days after MSC transplantation.
(d) Double-stained [Ly6C.sup.+]/IL-1[beta]+ cells scattered in the infarct area 2 days after dMCAO. (h) [Ly6C.sup.+]/IL-1[beta]+ cells in the infarct area 2 days after MSC transplantation.
(d) Double-stained [Ly6C.sup.+]/[TNF-[alpha].sup.+] cells scattered in the infarct area 2 days after dMCAO. (h) [Ly6C.sup.+]/[TNF-[alpha].sup.+] cells in the infarct area 2 days after MSC transplantation.
(d) No double-stained [Iba-1.sup.+]/[TNF-[alpha].sup.+] cells were found in the infarct area after dMCAO. (h) No [Iba-1.sup.+]/TNF-[alpha] cells was found 2 days after MSC transplantation in the striatum.