(redirected from dacarbazine)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to dacarbazine: doxorubicin, bleomycin, Temozolomide
DTICDefense Technical Information Center
DTICDacarbazine (chemotherapy drug)
DTICDimethyl Triazeno Imidazole Carboxamide
DTICDaegu Tourist Information Center (South Korea)
DTICDépartement Technologies de l'Information et de la Communication (French: Department of Information Technology and Communication)
DTICDavis Technologies International Group Corp
Copyright 1988-2018 AcronymFinder.com, All rights reserved.
References in periodicals archive ?
Additional Analyses of ECHELON-1 and ECHELON-2 Trials Presented at 2019 American Society of Clinical Oncology (ASCO) Annual Meeting: A three-year update of the ECHELON-1 trial continued to show superior clinical activity of ADCETRIS in combination with AVD compared to ABVD (Adriamycin, bleomycin, vinblastine and dacarbazine) in frontline stage III and IV HL.
The approval is based on the results of the randomized, open-label, two-arm, multi-center Phase 3 ECHELON-1 study designed to compare Adcetris plus AVD to ABVD (Adriamycin, bleomycin, vinblastine and dacarbazine) as a therapy in adult patients with previously untreated Hodgkin lymphoma.
Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine. Cancer Res.
Patients were randomized to receive either nivolumab (n = 210; 3 mg/kg every 2 weeks plus placebo every 3 weeks) or dacarbazine (n = 208; 1,000 mg/m2 every 3 weeks plus placebo every 2 weeks).
Hansson et al., "Bleomycin, vincristine, lomustine and dacarbazine (BOLD) in combination with recombinant interferon alpha-2b for metastatic uveal melanoma," European Journal of Cancer, vol.
The dosing of chemotherapy in this retrospective study varied greatly; however, the patients that received gemcitabine/docetaxel received 675 to 900mg/[m.sup.2] of gemcitabine and 75 to 100mg/[m.sup.2] of docetaxel; the patients that received doxorubicin-based regimens received 60 to 75 mg/[m.sup.2] of doxorubicin, 7.5 to 10gm/[m.sup.2] of ifosfamide, and 750 to 1000 mg/[m.sup.2] of dacarbazine. This is standard sarcoma chemotherapy dosing.
The absence of standard of care in these patients and the extrapolated data from the phase III trial of nab-paclitaxel when compared to dacarbazine [29] in patients with cutaneous melanoma led to the use of this agent in our patient who was not a candidate for cisplatin.
All but 1 patient had previously received at least 2 other treatments, including chemotherapy for 8, with dacarbazine, carboplatin, temozolomide, vindesine, fotemustine, or cyclophosphamide; vaccination for 4; anti-CTLA4 antibody ipilimumab for 2 (10 or 3mg/kg for 1 each); NCT00324155 protocol: dacarbazine (850mg/m2 every 3 weeks) + ipilimumab (10mg/kg every 3 weeks) for 2; NCT00338130 protocol comparing AstraZeneca AZD6244 versus temozolomide, radiotherapy delivered to a cutaneous metastasis on the lower limb, and surgery for small intestine resection.
In our study, Cisplatin, Etoposide, Bleomycin, Cyclophosphamide, Doxorubicin, Vincristine, 5-Flourouracil, Epirubicin, Paclitaxel, Vinblastine, Dacarbazine, Carboplatin, Ifosfamide, Docetaxel, Oxaliplatin, were responsible for alopecia, as also in previous studies.
(2) Historically, alkylating chemotherapy agents such as dacarbazine and temozolomide have been used with limited efficacy.
The older sister underwent surgical removal of the primary MM lesions, followed by chemotherapy with dacarbazine, nimustine, vincristine, and interferon at the Dermatology Department of our hospital in 2000.
Long term safety concerns which emerged with the use of radiotherapy led to use of chemotherapy alone for treatment of early-stage favorable risk HL resulting in more or less similar outcome as shown with CMT.12,13 Recent trials for patients with limited-stage HL have demonstrated that treatment with chemotherapy plus involved-field radiation therapy (IFRT) and chemotherapy alone with Doxorubicin (Adriamycin), Bleomycin, Vinblastine, and Dacarbazine (ABVD) may both be acceptable options for these patients.5,14 Some studies have highlighted the role of interim PET/CT to guide treatment; however, this approach may not be applicable everywhere because the availability of this imaging modality is still sparse in many countries.15,16