These LPS subgroup analyses showed that overall survival results favored eribulin compared to dacarbazine
across different histologic subtypes (dedifferentiated and pleomorphic) and tumor grades (high and intermediate).
For example, dacarbazine
resulted in a low response rate (10-15%) and an overall survival (OS) of eight months.
The study met its primary endpoint of improving progression-free survival (PFS) compared with dacarbazine
7-Not Estimable] and median duration of response for dacarbazine
treatment was 4.
Methods: The B16F10 cell line was treated with different concentrations of saponin (O, 4, 8, 12, 16, 20 [micro]g/ml), dacarbazine
(O, 1200, 1400, 1600, 1800, 2000 [micro]/ml) and coadministration of saponin-dacarbazine
(1200 da+8 sp, 1200 da+4 sp) for 24 and 48 hr and the cytotoxic effect was examined by MTT, DAPI, acridine orange/propodium iodide, flow cytometry and caspase colorimetric assay.
is chemotherapy used in cancer patients; its trade name is known as DETICENE, and have been purchased from (Medac, Germany).
The trial enrolled a total of 418 patients with treatment naive BRAF wild-type unresectable Stage III and IV melanoma and they were given either Opdivo 3mg/kg every two weeks or dacarbazine
1000mg/m2 every three weeks.
7 months among those randomized to chemotherapy with dacarbazine
, a statistically significant difference (hazard ratio, 0.
One group received trametinib, the other, standard chemotherapy--an intravenously administered drug called dacarbazine
Vical completed enrollment in February 2010 of 390 chemo-naive patients randomized on a 2:1 basis: 260 for treatment with Allovectin(R) and 130 for treatment with physician's choice of either dacarbazine
64% in the group receiving the more traditional chemotherapy drug, dacarbazine
One trial found 84% of the advanced melanoma patients taking Zelboraf survived for at least six months, compared to 64% of the patients taking a traditional chemotherapy drug called dacarbazine