The effects of tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone on CYP2D6-mediated dextromethorphan
metabolism in pooled human liver microsomes showed different degrees of concentration-dependent inhibition (Fig.
The benefit appears to stem from the fact that dextromethorphan
blocks the action of a chemical messenger known as NMDA, which helps relay pain signals to the brain.
The Oregon Poison Center in Portland answered 878 phone inquiries last year about dextromethorphan
effects experienced by people who took too much of the drug either intentionally or by accident, says Tonya Drayden, public education coordinator for the poison center.
was first approved in 1958 and was introduced as a replacement for codeine in cough medications.
According to the National Institute of Health (NIH), each year there are millions of cough/cold suffers and for many of these patients, self-medicating with long-acting dextromethorphan
will be the preferred option.
(DXM), the dextroisomer of levorphanol, is an opioid, but it has no analgesic properties and does not cause respiratory depression or central nervous system depression at therapeutic doses.
This mislabeling could cause the consumer to be unaware of side effects and/or risks associated with the ingestion of certain product ingredients which include Acetaminophen, Dextromethorphan
, Guaifenesin, Phenylephrine and/or Diphenhydramine.
Cases of dextromethorphan
abuse reported to the California Poison Control System increased 10-fold in all age groups--and increased 15-fold in adolescents--between 1999 and 2004, said Jodi K.
The NMDA-receptor-blocking drugs include opioids (such as methadone and levorphanol) and nonopioids (such as dextromethorphan
, ketamine, amantadine, and memantine).
50mg,325mg tablets of acetylsalicylic acid, 2 mg chlorpheniramine maleate, hydrobromide fenilfrina bitrate 8mg, 10mg dextromethorphan
hydrobromide,tablets of sodium bicarbonate, citric acid and aspirin
PRISM II Poster Presentation Details Title: PRISM II: An Open-Label Study to Assess the Safety, Tolerability, and Effectiveness of Dextromethorphan
20 mg/Quinidine 10 mg for Treatment of Pseudobulbar Affect Secondary to Dementia, Stroke, or Traumatic Brain Injury: Results from the Alzheimer's Disease/Dementia Cohort Poster Number: P7.
Web sites contain recipes for making dextromethorphan
cough syrups more palatable and provide instructions on how to extract it from Sucrets lozenges, Dr.