eIF4G

AcronymDefinition
eIF4GEukaryotic Translation Initiation Factor 4G
References in periodicals archive ?
By binding to the (7) methylguanosine cap structure of mRNA, eIF4El provides an interface that enables recruitment and engagement of eIF4A and eIF4G with the 40S ribosomal subunit.
They also differ in their abilities to bind eIF4G and 4E-BP as reflected in amino acid substitutions in their eIF4G/4E-BP-binding motifs (Joshi et al.
Picornavirus IRES elements are the examples of types I and II IRESes which require eIF4G, eIF4A, and eIF3 to assemble 48S initiation complex [29].
This shift is attributed to eIF2[alpha] phosphorylation, eIF4E-BP dephosphorylation, and eIF4G cleavage, any of which can inhibit canonical translation initiation [33, 36].
Defects in the ATPase domain of Ded1 or overexpression of DED1 lead to the accumulation of SGs because Ded1 functions both as a repressor of translation (by forming an eIF4F-Ded1-mRNA complex via interaction with eIF4G) and as an activator of translation through its ATP hydrolysis activity [40].
The eIF4 complex is composed of three polypeptides: eIF4E (the cap binding protein), eIF4A (an RNA helicase), and eIF4G (scaffolding protein).
Quando a 4E-BP1 e fosforilada, o eIF4E e liberado e pode unir-se, ao eIF4G e o qual esta tambem sob o controle do MTOR e ao eIF4A, formando o complexo ribossomal eIF4F.
Formation of the eIF4F complex is regulated by competition between eIF4E binding proteins (4EBPs) and eIF4G for binding to eIF4E.
Mais precisamente a ativacao da via de sinalizacoes da AMPK, atenua a sintese proteica atraves da inibicao da sinalizacao da mTOR, via ativacao do complexo TSC, associada tambem com uma reduzida inibicao das proteinas ligantes ao eIF4E (4EBP1) e uma reducao no eIF4E associado ao eIF4G.
eIF4F is a heterotrimeric complex composed of the cap-binding protein eIF4E, the scaffold protein eIF4G, and the RNA helicase eIF4A.
Ja na infusao de leucina apos a administracao de somatostatina, observou-se atenuacao no aumento induzido pela leucina sobre fosforilacao da 4E-BP1 e da S6K1, porem nao tem efeito sobre a associacao do eIF4E e eIF4G. O resultado desse estudo sugere que a inducao da sintese proteica pela leucina seguida da fosforilacao das proteinas 4E-BP1 e S6K1 e facilitada pelo aumento nas concentracoes sericas de insulina, enquanto os efeitos independentes de insulina sao mediados por um mecanismo ainda nao totalmente esclarecido, que envolve a fosforilacao do eIF4E e/ou sua associacao com o eIF4G.