(NSE) is a dimeric isoenzyme of the glycolytic enzyme enolase
Divergent evolution in the enolase
superfamily: the interplay of mechanism and specificity.
Among neuroendocrine markers, Neuron Specific Enolase
(NSE) was most frequent expressed, being positive in 18 out of 22 (81.
In this study, we identified Filensin like protein, Gelsolin, Vimentin, Gamma enolase
like protein and ATP synthase subunit B from insoluble fraction of Uromastyx hardwickii lens.
The tumor stains positively for (b) neuron-specific enolase
, (c) vimentin, (d) synaptophysin, and (e) S-100 protein.
Cytohrome c (MW ~ 12 384; [greater than or equal to] 95%), enolase
(MW ~ 93 068; [greater than or equal to] 50%), lactate dehydrogenase (MW ~ 142 000; ~50%), and L-glutamic dehydrogenase (MW ~ 290 000) were purchased from Sigma-Aldrich (St.
For example, the enolases
(ENOA) and gamma-enolase
(ENOG) participate in glucose metabolism, and eukaryotic translation initiation factor 4B, which binds ribosomes and functions in synthetic processes, contributes to cell growth and maintenance.
3) SNUC generally stains positively for cytokeratin, with variable staining for the neuroendocrine markers chromogranin, neuron-specific enolase
, synaptophysin, and S-100.
Neuron specific enolase
(NSE) is a cytoplasmic glycolytic enzyme that was primarily detected in the cells of neuroectodermal origin and in neuronal cells.
Neuroendocrine cells are characterized by the expression of marker molecules like neuron-specific enolase
(NSE), an unspecific cytosolic marker or vesicle proteins like chromogranin A or synaptophysin, indicating a dense hormonestoring core vesicles and neuropeptides or small neurotransmitter storing synaptic vesicles .
However, neuron-specific enolase
(NSE) was significantly higher (289.
Immunohistochemical studies showed positive immunoreactivity of neoplastic cells to cytokeratin and chromogranin [Figure 4a and b], and negative reactivity with AFP, CEA, vimentin, leukocyte common antigen (LCA), CD20 antigen, and neuron-specific enolase